Journal ArticleDOI
Adverse drug reactions: definitions, diagnosis, and management.
TLDR
An adverse drug reaction is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product.About:
This article is published in The Lancet.The article was published on 2000-10-07. It has received 2442 citations till now. The article focuses on the topics: Adverse drug reaction & Challenge–dechallenge–rechallenge.read more
Citations
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Journal ArticleDOI
Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
Patrick Kwan,Alexis Arzimanoglou,Anne T. Berg,Martin J. Brodie,W. Allen Hauser,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Samuel Wiebe,Jacqueline A. French +9 more
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Munir Pirmohamed,Sally James,Shaun Meakin,Chris D. Green,A Scott,Tom Walley,Keith Farrar,B. Kevin Park,Alasdair Breckenridge +8 more
TL;DR: The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.
Journal ArticleDOI
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
TL;DR: This research presents a novel and scalable approach called “informed consent” that aims to provide real-time information about the pros and cons of surgery on the basis of prior history and once-in-a-lifetime data.
Journal ArticleDOI
Better reporting of harms in randomized trials: an extension of the CONSORT statement.
John P. A. Ioannidis,Stephen J. W. Evans,Peter C Gøtzsche,Robert T O'Neill,Douglas G. Altman,Kenneth F. Schulz,David Moher +6 more
TL;DR: This work searched MEDLINE, EMBASE, Web of Science, and the Cochrane Library using a wide array of terms related to harms and identified pertinent evidence and made recommendations on the appropriate reporting of harms in RCTs.
References
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Journal ArticleDOI
Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies
TL;DR: The incidence of serious and fatal adverse drug reactions in US hospitals was found to be extremely high, and data suggest that ADRs represent an important clinical issue.
Journal ArticleDOI
Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
David W. Bates,D J Cullen,Nan M. Laird,Laura A. Petersen,Small Sd,Servi D,G Laffel,Bobbie Jean Sweitzer,Shea Bf,Hallisey R +9 more
TL;DR: Adverse drug events were common and often preventable; serious ADEs were more likely to be preventable and prevention strategies should target both stages of the drug delivery process.
Journal ArticleDOI
Incidence of adverse drug events and potential adverse drug events
Journal ArticleDOI
Prescribing behaviour in clinical practice: patients' expectations and doctors' perceptions of patients' expectations—a questionnaire study
Jill Cockburn,Sabrina Winona Pit +1 more
TL;DR: It was the doctors' opinions about patients' expectations that were the strongest determinants of prescribing with the increasing promotion of rational prescribing, practitioners need to be aware of these influences on prescribing.