Journal ArticleDOI
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
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TLDR
This research presents a novel and scalable approach called “informed consent” that aims to provide real-time information about the pros and cons of surgery on the basis of prior history and once-in-a-lifetime data.Abstract:
*Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; yInstitute for Children and Adolescents with Epilepsy-IDEE, University Hospital of Lyon (HCL) and Inserm U821, Lyon, France; zDepartment of Biology, Northern Illinois University, DeKalb, Illinois, U.S.A.; xEpilepsy Unit, Western Infirmary, Glasgow, United Kingdom;{GH Sergievsky Center, Columbia University, New York, New York, U.S.A.; #Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.; **The Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience and Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, U.S.A.; yyClinical Trial Center, Institute of Neurology IRCCS C. Mondino Foundation, and Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; zzDepartment of Clinical Neurosciences, University of Calgary, and Hotchkiss Brain Institute, Calgary, Alberta, Canada; and xxNYU Comprehensive Epilepsy Center, New York, New York, U.S.A.read more
Citations
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Journal ArticleDOI
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Orrin Devinsky,J. Helen Cross,Linda Laux,Eric D. Marsh,Ian Miller,Rima Nabbout,Ingrid E. Scheffer,Elizabeth A. Thiele,Stephen Wright +8 more
TL;DR: Among patients with the Dravet syndrome, cannabidiol resulted in a greater reduction in convulsive‐seizure frequency than placebo and was associated with higher rates of adverse events.
Journal ArticleDOI
Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy: A Randomized Trial
Jerome Engel,Michael P. McDermott,Samuel Wiebe,John T. Langfitt,John M. Stern,Sandra Dewar,Michael R. Sperling,Irenita Gardiner,Giuseppe Erba,Itzhak Fried,Margaret Jacobs,Harry V. Vinters,Scott Mintzer,Karl Kieburtz +13 more
TL;DR: Whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued medical management in controlling seizures and improving quality of life (QOL) is sought and among patients with newly intractable disabling MTLE, resective surgery plus AED treatment resulted in a lower probability of seizures during year 2 of follow-up than continued AEDtreatment alone.
Journal ArticleDOI
Drug-Resistant Epilepsy
TL;DR: A review examines how this diagnosis should be established and how to recognize pseudoresistance and explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Journal ArticleDOI
Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.
TL;DR: Overall outcomes in newly diagnosed epilepsy have not improved and most patients who attain control do so with the first or second AED, although the probability of achieving seizure freedom diminishes substantially with each subsequent AED regimen tried.
Journal ArticleDOI
Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.
TL;DR: Preclinical strategies of AED discovery and development need a conceptual shift that is moving away from using models that identify therapies for the symptomatic treatment of epilepsy to those that may be useful for identifying therapies that are more effective in the refractory population.
References
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Journal ArticleDOI
Early Identification of Refractory Epilepsy
TL;DR: Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Journal ArticleDOI
Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.
Patrick Kwan,Alexis Arzimanoglou,Anne T. Berg,Martin J. Brodie,W. Allen Hauser,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Samuel Wiebe,Jacqueline A. French +9 more
TL;DR: It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Journal ArticleDOI
Adverse drug reactions: definitions, diagnosis, and management.
TL;DR: An adverse drug reaction is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product.
Journal ArticleDOI
The clinical course of epilepsy and its psychosocial correlates: findings from a U.K. Community study.
TL;DR: There was a clear relationship between current seizure frequency and levels of anxiety and depression, perceived impact of epilepsy, perceived stigma, and marital and employment status, and there was little evidence that psychosocial functioning was associated with length of remission.
Journal ArticleDOI
Toward the operational identification of adverse drug reactions.
Fred E. Karch,Louis Lasagna +1 more
TL;DR: A decision table algorithm approach is presented toward the development of an operational system for the identification of adverse drug reactions that incorporates an estimate of the certainty of the link between the untoward clinical event and the suspect drug, and examines the underlying causes of the identified drug reactions.