An analysis of the responses of the isolated portal vein of the rabbit to electrical stimulation and to drugs.
J. Hughes,J. R. Vane +1 more
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This article is published in British journal of pharmacology and chemotherapy.The article was published on 1967-05-01 and is currently open access. It has received 116 citations till now.read more
Citations
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Physiology and Pathophysiology of Purinergic Neurotransmission
TL;DR: This review is focused on purinergic neurotransmission, i.e., ATP released from nerves as a transmitter or cotransmitter to act as an extracellular signaling molecule on both pre- and postjunctional membranes at neuroeffector junctions and synapses, as well as acting as a trophic factor during development and regeneration.
Journal ArticleDOI
Roles of P2-purinoceptors in the cardiovascular system.
Vera Ralevic,Geoffrey Burnstock +1 more
TL;DR: The net effect of ATP and its analogues on isolated vessels or on vascular beds will be the results of actions mediated by P2X- and P2Y-purinoceptor subtypes, although changes in vascular tone and in integrity of nerves and endothelial cells may alter the balance of the response.
Journal ArticleDOI
Purinergic Signaling and Blood Vessels in Health and Disease
Geoffrey Burnstock,Vera Ralevic +1 more
TL;DR: The long-term (trophic) actions of purine and pyrimidine nucleosides and nucleotides in promoting migration and proliferation of both vascular smooth muscle and endothelial cells via P1 and P2Y receptors during angiogenesis and vessel remodeling during restenosis after angioplasty are described.
Journal ArticleDOI
Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle.
Ronald F. Coburn,T. Tomita +1 more
TL;DR: It is suggested that all or most of the inhibitory innervation of guinea pig trachealis muscle is nonadrenergic, as evidenced by partial suppression of field-stimulation relaxations with beta-blocking drugs and sensitivity to the adrenergic neuron-blocking effects of bretylium.
References
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Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
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A study of the adrenotropic receptors
TL;DR: Experiments described in this paper indicate that although there are two kinds of adrenotropic receptors they cannot be classified simply as excitatory or inhibitory since each kind of receptor may have either action depending upon where it is found.
Journal ArticleDOI
Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons
TL;DR: Observations have been made of sodium and potassium currents in the lobster giant axons treated with tetrodotoxin by means of the sucrose-gap voltage-clamp technique, and it is concluded that tetrodOToxin blocks the action potential production through its selective inhibition of the sodium-carrying mechanism while keeping the potassium- Carrying mechanism intact.
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