Journal ArticleDOI
An assessment of grip strength measurement in rheumatoid arthritis.
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TLDR
Grip strength is responsive to Sodium Salicylate and Prednisolone therapy but the change in association with the former was minimal—indicating insensitivity of the test.Abstract:
The intra-observer, inter-observer, day-to-day, week-to-week and diurnal variations in grip strength measurement have been studied in patients with rheumatoid arthritis. In addition, the changes in grip strength measurements in a double-blind, cross-over trial of Sodium Salicylate and Prednisolone are reported. An intra-observer error of up to 9 mmHg was found and, in addition, there was also considerable variation in grip strength measurements between different observers. Grip strength is responsive to Sodium Salicylate and Prednisolone therapy but the change in association with the former was minimal—indicating insensitivity of the test. In clinical trials, measurement of grip strength should not only be performed by one observer for each patient but measurements should be made at the same time of day because of its diurnal variation. The inherent errors in the method should be considered when interpreting results of grip strength measurement in such trials.read more
Citations
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Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years
Theodore Pincus,Leigh F. Callahan,William G. Sale,Arthur L. Brooks,Lee E. Payne,William K. Vaughn +5 more
TL;DR: There was increased mortality at the 9-year review, similar to most reported series of RA patients from referral centers; however, a significant increase in neoplasia, which was of concern because of the use of intraarticular thiotepa, was not seen.
Journal ArticleDOI
Minocycline in rheumatoid arthritis : a 48-week, double-blind, placebo-controlled trial
Barbara C. Tilley,Graciela S. Alarcón,Stephen P. Heyse,David E. Trentham,Rosemarie Neuner,David L. Kaplan,Daniel O. Clegg,James C. C. Leisen,Lenore M. Buckley,Sheldon M. Cooper,Howard Duncan,Stanley R. Pillemer,Marilyn Tuttleman,Sarah Fowler +13 more
TL;DR: A 48-week, randomized, double-blind, multicenter trial to determine the efficacy and safety of minocycline in treating rheumatoid arthritis when it is added to background NSAIDs or low-dose prednisone therapy in patients not receiving concomitant disease-modifying antirheumatic drugs.
Journal ArticleDOI
Methodology and Overt and Hidden Bias in Reports of 196 Double-Blind Trials of Nonsteroidal Antiinflammatory Drugs in Rheumatoid Arthritis
TL;DR: Important design aspects were decreasingly reported in NSAID trials over the years, whereas the quality of statistical analysis improved, and it is not obvious how a reliable meta-analysis could be done in these trials.
Journal ArticleDOI
Formal education as a marker for increased mortality and morbidity in rheumatoid arthritis
TL;DR: Formal educational level appears a simple quantitative marker which identifies a surrogate or composite variable associated with increased mortality and morbidity in RA.
Journal ArticleDOI
Formal education level as a significant marker of clinical status in rheumatoid arthritis
TL;DR: Although patients seen at the Veterans Administration Medical Center had lower levels of formal education than those seen at a university clinic and private practices, trends in clinical status according to formal education level were similar in all three clinical settings.
References
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Journal ArticleDOI
Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.
Dorothy M. Ritchie,James A. Boyle,John M. Mcinnes,Mukundrai K. Jasani,Theodore G. Dalakos,Phillida Grieveson,W. Watson Buchanan +6 more
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A sphygmomanometer for epidemiologists
Journal ArticleDOI
Report of a three-year study on the systemic and articular indexes in rheumatoid arthritis; theoretic and clinical considerations
TL;DR: The author's methods of systemic and articular indexes have been an important advance in the field of evaluating disease activity and response to therapy in patients with rheumatoid arthritis.
Journal ArticleDOI
Evaluation of a functional index in rheumatoid arthritis.
TL;DR: An index of functional impairment is described for use in the assessment of rheumatoid arthritis and does not show change in short-term clinical trials of antiinflammatory drugs, but does change with significant improvement in the patient's functional ability, following major reconstructive joint surgery.