Journal ArticleDOI
Analysis of pharmacokinetic data using parametric models. II. Point estimates of an individual's parameters
TLDR
This is the second in a series of tutorial articles discussing the analysis of pharmacokinetic data using parametric models, and primary emphasis is placed on point estimates of the parameters of the structural (pharmacokinetic) model.Abstract:
This is the second in a series of tutorial articles discussing the analysis of pharmacokinetic data using parametric models. In this article the basic issue is how to estimate the parameters of such models. Primary emphasis is placed on point estimates of the parameters of the structural (pharmacokinetic) model. All the estimation methods discussed are least squares (LS) methods: ordinary least squares, weighted least squares, iteratively reweighted least squares, and extended least squares. The choice of LS method depends on the variance model. Some discussion is also provided of computer methods used to find the LS estimates, identifiability, and robust LS-based estimation methods.read more
Citations
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Sampling and Bayes' inference in scientific modelling and robustness
TL;DR: In this article, the authors consider the problem of bad value estimation from a Bayesian viewpoint and compare the performance of M estimators with predictive checking functions for transformation, serial correlation, bad values, and their relation with Bayesian options.
Journal ArticleDOI
The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors.
TL;DR: The analgesic potency of dexmedetomidine was enhanced after nerve injury with a site of action outside the central nervous system and may have shifted the site of alpha2 analgesic action to outside the blood-brain barrier.
Journal ArticleDOI
An unbiased parametric imaging algorithm for nonuniformly sampled biomedical system parameter estimation
TL;DR: This algorithm is particular useful in image-wide (pixel-by-pixel based) parameter estimation, e.g., to generate parametric images from tracer dynamic studies with positron emission tomography and is also generally applicable to other continuous system parameter estimation.
Journal ArticleDOI
Review of methods and criteria for the evaluation of bioequivalence studies.
TL;DR: It is recommended that concentration-dependent data of bioequivalence studies be evaluated by analysis of variance after logarithmic transformation, applying general linear models.
References
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Practical Methods of Optimization
TL;DR: The aim of this book is to provide a Discussion of Constrained Optimization and its Applications to Linear Programming and Other Optimization Problems.
Journal ArticleDOI
A Note on the Generation of Random Normal Deviates
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Mathematical Statistics: Basic Ideas and Selected Topics
Peter J. Bickel,Kjell A. Doksum +1 more
TL;DR: In this paper, the authors present a review of basic probability theory and its application in statistical models, goals, and performance criteria, as well as several non-decision theoretic criteria.
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Actin and myosin and cell movement.
Thomas D. Pollard,Weihing Rr +1 more
TL;DR: The CRC Critical Reviews in Biochemistry: Vol. 2, No. 1, No. 1, pp. 1-65 as mentioned in this paper, reviewed Actin And Myosin And Cell Movemen.
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