Journal ArticleDOI
Angiogenesis in Cervical Neoplasia: Microvessel Quantitation in Precancerous Lesions and Invasive Carcinomas with Clinicopathological Correlations☆
Athanassios Dellas,Holger Moch,Elisabeth Schultheiss,Georg Feichter,Alfonso C. Almendral,Fred Gudat,Joachim Torhorst +6 more
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TLDR
A Cox stepwise regression analysis revealed microvessel density, together with depth of invasion, regional lymph node status, and vascular invasion, to be a strong independent prognostic indicator for overall survival in patients with clinical stage IB cervical carcinoma.About:
This article is published in Gynecologic Oncology.The article was published on 1997-10-01. It has received 109 citations till now. The article focuses on the topics: Cervical intraepithelial neoplasia & Microvessel.read more
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Journal ArticleDOI
Ki67 protein: the immaculate deception?
D.C. Brown,K C Gatter +1 more
TL;DR: In this paper, the authors provide an update on the characterization of the Ki67 protein, its function and its use as a prognostic or diagnostic tool, as well as the number of papers published featuring this antibody has increased 10-fold from 338 to 3489.
Journal ArticleDOI
Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications
Rebekah A. Drezek,Konstantin V Sokolov,Urs Utzinger,Iouri Boiko,Anais Malpica,Michele Follen,Rebecca Richards-Kortum +6 more
TL;DR: In this article, a Monte Carlo model was developed to quantitatively examine how intrinsic NADH and collagen fluorescence, in combination with tissue scattering and ab- sorption properties, yield measured tissue spectra.
Journal ArticleDOI
Reflectance spectroscopy for in vivo detection of cervical precancer
Yvette N. Mirabal,Sung K. Chang,Edward N. Atkinson,Anais Malpica,Michele Follen,Rebecca Richards-Kortum +5 more
TL;DR: Reflectance spectroscopy appears promising for in vivo detection of cervical precancer through accurate, objective, instantaneous point-of-care diagnostic tools.
Journal ArticleDOI
Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer
Sung K. Chang,Yvette N. Mirabal,Edward N. Atkinson,Dennis D. Cox,Anais Malpica,M. Follen,Rebecca Richards-Kortum +6 more
TL;DR: Fluorescence emission spectra at 330- to 360-nm and 460- to 470-nm excitation provide the best diagnostic performance for separating all pairs of tissue categories, except in the case of discriminating high-grade precancers from columnar normal tissue.
Journal ArticleDOI
The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix.
TL;DR: It is suggested that MC tryptase may upregulate neoangiogenesis in carcinogenesis of the uterine cervix, and increase with tumor progression and were close to newly formed blood vessels.
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