Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TLDR
Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.About:
This article is published in Journal of the National Cancer Institute.The article was published on 1990-01-03. It has received 4637 citations till now. The article focuses on the topics: Angiogenesis.read more
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Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
Alan B. Sandler,Robert Gray,Michael C. Perry,Julie R. Brahmer,Joan H. Schiller,Afshin Dowlati,Rogerio Lilenbaum,David H. Johnson +7 more
TL;DR: The addition of bevacizumab to paclitaxel plus carboplatin in the treatment of selected patients with non-small-cell lung cancer has a significant survival benefit with the risk of increased treatment-related deaths.
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
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The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
References
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Induction of angiogenesis during the transition from hyperplasia to neoplasia
TL;DR: It is reported here that angiogenic activity first appears in a subset of hyperplastic islets before the onset of tumour formation, suggesting that induction of angiogenesis is an important step in carcinogenesis.
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Tumor dormancy in vivo by prevention of neovascularization.
TL;DR: The data suggest that the specific blockade of tumor-induced angiogenesis may be an effective means of controlling neoplastic growth.
Journal Article
Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation.
TL;DR: It is suggested that dynamics of hematogenously initiated metastases depend strongly on the entry rate of tumor cell clumps into the circulation, which in turn is intimately linked to tumor vascularization.