Antenatal diagnosis of fetal abnormality with special reference to amniocentesis.
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This article is published in Journal of the Royal Society of Medicine.The article was published on 1973-11-01 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Amniocentesis & Prenatal diagnosis.read more
Citations
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Book ChapterDOI
The Prenatal Diagnosis of Chromosomal Disorders
TL;DR: The ability to determine the fetal karyotype from cultured amniotic fluid cells was achieved independently by Klinger and by Steele and Breg (1966), and Valenti et al. (1969) reported the first prenatal diagnosis of Down syndrome.
Journal ArticleDOI
Ultrasonic placental localization in relation to spontaneous abortion after mid-trimester amniocentesis.
TL;DR: This paper summarizes the experience with a series of 562 women referred for mid‐trimester amniocentesis for prenatal diagnosis and finds no significant difference in the incidence of fetal loss or spontaneous abortion in patients having an anterior versus a posterior placenta.
Journal ArticleDOI
Prenatal detection of D trisomy
TL;DR: The second instance of a prenatally diagnosed fetus of D trisomy is reported in a 45-year-old woman and the fetus had bilateral hare lip and cleft palate, arrhinencephaly, and numerous other malformations.
Journal ArticleDOI
En Belgique francophone: philosophie du calcul du risque pour la trisomie 21 et informations aux futurs parents
Abstract: Introduction — problemes conceptuels
L’information a donner aux futurs parents avant les tests de calcul de risque pour la trisomie 21 est tres complexe, en raison notamment de la rapidite avec laquelle le depistage s’est mis en place, de la difficulte a gerer les faux-negatifs, les fauxpositifs et les fausses couches induites. S’ajoute a cela qu’un depistage implicite se fait inevitablement et, finalement, que l’acceptation de la trisomie est eminemment variable.
Journal ArticleDOI
The handicapped child.
TL;DR: Most handicapped children are afflicted early in life and long before they have acquired many skills, so they have to be trained to develop even basic skills such as walking in the case of a cerebral palsy baby.
References
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Journal ArticleDOI
Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida.
David J. H. Brock,R.G. Sutcliffe +1 more
TL;DR: Results suggest that amniotic-fluid-A.F.P. measurements will be valuable in the early antenatal diagnosis of anencephaly and spina bifida and will enable termination of these pregnancies.
Journal ArticleDOI
Anencephaly: early ultrasonic diagnosis and active management.
TL;DR: It is suggested that ultrasound examination should be carried out in all patients who, in a previous pregnancy, were delivered of an anencephalic fetus or a baby with spina bifida.
Journal ArticleDOI
Alpha-fetoprotein in antenatal diagnosis of anencephaly and spina bifida.
TL;DR: Of 38 subjects undergoing amniocentesis for antenatal spina bifida detection 1 case is reported in which a raised alpha fetoprotein (AFP) level was detected and led to pregnancy termination and the fetus delivered had anencephaly and a large spina Bifida.
Journal ArticleDOI
Amniocentesis in genetic counseling. Safety and reliability in early pregnancy.
Albert B. Gerbie,Albert B. Gerbie,Henry L. Nadler,Henry L. Nadler,Melvin V. Gerbie,Melvin V. Gerbie +5 more
TL;DR: Amniotic fluid obtained early in pregnancy has been utilized successfully to detect genetic defects of the fetus and analysis of this fluid may eliminate the uncertainty in genetic counseling by identifying a fetus with a serious genetic defect.
Journal ArticleDOI
Management of inherited metabolic disease.
TL;DR: The present contribution is intended to define some of the problems and provide a framework on to which individual knowledge and experience can be grafted in the field of mental retardation.