Journal ArticleDOI
Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark.
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TLDR
Phytochemical studies of an ethanolic extract of Euclea natalensis root bark afforded two new compounds, octahydroeuclein and 20(29)-lupene-3 beta-isoferulate, in addition to three known compounds, shinanolone, lupeol, and betulin.Abstract:
Phytochemical studies of an ethanolic extract of Euclea natalensis root bark afforded two new compounds, octahydroeuclein (1) and 20(29)-lupene-3 beta-isoferulate (2), in addition to three known compounds, shinanolone (3), lupeol, and betulin. The chemical structures of 1 and 2 were determined by spectroscopic means. Shinanolone (3) showed inhibitory activity against Gram-positive bacterial strains and a drug-sensitive strain of Mycobacterium tuberculosis at a concentration of 0.1 mg/mL.read more
Citations
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Biological Activities of Lupeol
TL;DR: These studies provide insight into the mechanism of action of lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B, cFLIP, Fas, Kras, phosphatidylinositol-3-kinase in a variety of cells.
Journal ArticleDOI
The potential of South African plants against Mycobacterium infections.
TL;DR: Much work remains to be done on the systematic assessment of anti-TB efficacy of local plants against pathogenic Mycobacterium species, both in vitro and in vivo.
Journal ArticleDOI
Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes
TL;DR: Screening of plant extracts scientifically validated traditional use of Euclea undulata for treatment of diabetes and revealed that acetone extracts of Schkuhria pinnata and Elaeodendron transvaalense are toxic and raise concern for chronic use.
Journal ArticleDOI
Plants: A Source for New Antimycobacterial Drugs
TL;DR: 127 antimycobacterial compounds and their antimyCobacterial activities are reported and it is hoped that some of these compounds may eventually develop into effective new drugs against tuberculosis.
Journal ArticleDOI
Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase
Anita Mahapatra,Sannah P.N. Mativandlela,Brigitte Binneman,P.B. Fourie,Chris J. Hamilton,J.J.M. Meyer,F. van der Kooy,Peter J. Houghton,Namrita Lall +8 more
TL;DR: A series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Mycobacterium tuberculosis.
References
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The influence of natural products upon drug discovery.
Book
Field Guide to Trees of Southern Africa
Braam van Wyk,Piet van Wyk +1 more
TL;DR: The Field Guide to Trees of Southern Africa as discussed by the authors is a practical book that can be enjoyed by any person interested in forestry and the plant sciences in general, it illustratively and descriptively highlights a mixture of alien and natural vegetation types of South Africa.
Journal ArticleDOI
Evaluation of rapid radiometric method for drug susceptibility testing of Mycobacterium tuberculosis.
TL;DR: The results of this preliminary study indicate that the rapid radiometric method seems to have the potential for routine laboratory use and merits further investigations.
Journal ArticleDOI
In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants
Namrita Lall,J.J.M. Meyer +1 more
TL;DR: Twenty South African medicinal plants used to treat pulmonary diseases were screened for activity against drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis and acetone as well as water plant extracts inhibited the growth of M. tuberculosis.
Journal ArticleDOI
Comparison of viral isolation, direct immunofluorescence, and indirect immunoperoxidase techniques for detection of genital herpes simplex virus infection.
TL;DR: These commercially available rapid viral diagnostic techniques are specific and useful, if adequate specimens are obtained from early genital lesions, and during the vesicular-pustular stage of the disease, VI was positive in 90%, indirect IP waspositive in 76%, and direct FA was positive In 71% of the lesions, whereas with ulcerative lesions.
Related Papers (5)
In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants
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