Antibiotic resistance patterns among group B Streptococcus isolates: implications for antibiotic prophylaxis for early-onset neonatal sepsis
F. Capanna,Stéphane Emonet,Abdessalam Cherkaoui,Olivier Irion,Jacques Schrenzel,Begoña Martinez de Tejada +5 more
Reads0
Chats0
TLDR
These antibiotics should not be used for GBS neonatal sepsis prevention, without adequate antimicrobial susceptibility testing, and in case of penicillin allergy and lack of antibiogramm, cephalosporins or vancomycin should be used as recommended in CDC guidelines.Abstract:
Summary STUDY/PRINCIPLES: Antibiotic prophylaxis of Group B Streptococcus (GBS) positive women during labour reduces the risk of early-onset neonatal sepsis. Penicillin is the first choice, and clindamycin and erythromycin are second choices for penicillin-allergic women. Resistance to these antibiotics is rising. The aims of this study were to evaluate the rates of clindamycin and erythromycin resistance among GBS-positive isolates cultures from pregnant women in the University Hospital of Geneva and to evaluate the legitimacy of new Centres for Disease Control and Prevention (CDC) recommendations for our context. METHODS: We collected a vagino-rectal swab from pregnant women at 35‐37 weeks gestation. We recovered 124 GBS positive isolates. Identification was based on the characteristic of the colony on the chromogenic agar, the streptococcal agglutination test and confirmation by mass spectrometry. Antimicrobial susceptibility was determined by disk diffusion, according to CLSI guidelines 2010. RESULTS: The rate of resistance to clindamycin was 28% and to erythromycin was 30%. Only 3 of the 38 erythromycin resistant strains (7.9%) were susceptible to clindamycin, and only 3 out of the 35 clindamycin resistant GBS (8.6%) were identified as “inducible resistance”. The rate of co-resistance to clindamycin of erythromycin-resistant strains was 92%. Penicillin remained efficacious in all cases. CONCLUSION: Rates of clindamycin and erythromycin resistance are also increasing in our context. These antibiotics should not be used for GBS neonatal sepsis prevention, without adequate antimicrobial susceptibility testing. In case of penicillin allergy and lack of antibiogramm, cephalosporins or vancomycin should be used as recommended in CDC guidelines.read more
Citations
More filters
Journal ArticleDOI
Adverse events in women and children who have received intrapartum antibiotic prophylaxis treatment: a systematic review
Farah Seedat,Chris Stinton,Jacoby Patterson,Julia Geppert,Bee K. Tan,Bee K. Tan,Esther Robinson,Noel D. McCarthy,Olalekan A. Uthman,Karoline Freeman,Samantha Johnson,Hannah Fraser,Colin S Brown,Aileen Clarke,Sian Taylor-Phillips +14 more
TL;DR: The evidence base to determine the frequency of adverse events from intrapartum antibiotic prophylaxis for neonatal GBS disease prevention is limited and large, better quality, and longitudinal observational studies across countries with widespread IAP could fill this gap.
Journal ArticleDOI
Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paraná, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants.
Eliane Saori Otaguiri,Ana Elisa Belotto Morguette,Eliandro Reis Tavares,Pollyanna Myrella Capela dos Santos,Alexandre Tadachi Morey,Juscélio Donizete Cardoso,Marcia Regina Eches Perugini,Lucy Megumi Yamauchi,Sueli Fumie Yamada-Ogatta +8 more
TL;DR: The results indicate the potential virulence of commensal GBS isolates, reinforcing the need for continued screening for this bacterium to prevent infections.
Journal ArticleDOI
Evaluation of the Results of Group B Streptococcus Screening by MALDI-TOF MS among Pregnant Women in a Hungarian Hospital.
TL;DR: An analysis of the MALDI-TOF MS spectra of 260 GBS isolates revealed that 46.5% of them belonged to either the ST-1 or theST-17 sequence types, indicating a high prevalence of these potentially invasive GBS strains in the authors' region.
Journal ArticleDOI
Molecular epidemiology and distribution of serotypes, genotypes, and antibiotic resistance genes of Streptococcus agalactiae clinical isolates from Guelma, Algeria and Marseille, France.
A. Bergal,Lotfi Loucif,Lotfi Loucif,D. E. Benouareth,Ahmed Aimen Bentorki,Cédric Abat,Jean-Marc Rolain +6 more
TL;DR: The results provide epidemiological data in Guelma, Algeria and Marseille, France that establish a basis for monitoring increased resistance to erythromycin and also provide insight into correlations among clones, serotypes, and resistance genes.
Journal ArticleDOI
Intrapartum chemoprophylaxis of early-on-set group b streptococcal disease
TL;DR: Findings support the usefulness of ampicillin prophylaxis in the prevention of early-onset group B streptococcal sepsis.
References
More filters
A Systematic Review and Meta-analysis
TL;DR: A systematic review of studies published from January 1, 1950, through November 31, 2008 using PubMed, EMBASE, Web of Knowledge, CINAHL, and all Evidence-Based Medicine Reviews found that randomized clinical trials and prospective studies of RRTs that reported data on changes in the primary outcome of hospital mortality or the secondary outcome of cardiopulmonary arrest cases were included.
Journal Article
Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC.
TL;DR: Although universal screening for GBS colonization is anticipated to result in further reductions in the burden of GBS disease, the need to monitor for potential adverse consequences of intrapartum antibiotic use, such as emergence of bacterial antimicrobial resistance or increased incidence or severity of non-GBS neonatal pathogens, continues.
Journal ArticleDOI
Group B Streptococcal Disease in the Era of Intrapartum Antibiotic Prophylaxis
Stephanie J. Schrag,Sara Zywicki,Monica M. Farley,Arthur Reingold,Lee H. Harrison,Lewis B. Lefkowitz,James L. Hadler,Richard Danila,Paul R. Cieslak,Anne Schuchat +9 more
TL;DR: Over a six-year period, there has been a substantial decline in the incidence of group B streptococcal disease in newborns, including a major reduction in the excess incidence of these infections in black infants.
Journal ArticleDOI
Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005.
Christina R. Phares,Ruth Lynfield,Monica M. Farley,Janet C. Mohle-Boetani,Lee H. Harrison,Susan Petit,Allen S. Craig,William Schaffner,Shelley M. Zansky,Ken Gershman,Karen Stefonek,Bernadette A. Albanese,Elizabeth R. Zell,Anne Schuchat,Stephanie J. Schrag +14 more
TL;DR: In this article, an analysis of active, population-based surveillance in 10 states participating in the Active Bacterial Core surveillance/Emerging Infections Program Network was performed to describe disease trends among populations that might benefit from vaccination and among newborns during a period of evolving prevention strategies.
Journal ArticleDOI
Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis.
TL;DR: It is concluded that intrapartum ampicillin prophylaxis in women with positive prenatal cultures for group B Streptococci who have certain perinatal risk factors can prevent early-onset neonatal group B streptococcal disease.