Journal ArticleDOI
Antiinflammatory drugs: protection of a bacterial virus as an in vitro biological measure of free radical activity.
TLDR
The sulphur-containing drugs, metiazinic acid, piroxicam, penicillamine and sulindac as well as the indole derivative indomethacin, protect the virus from inactivation by the model peroxy radical CC13O2.About:
This article is published in Chemico-Biological Interactions.The article was published on 1983-12-01. It has received 67 citations till now. The article focuses on the topics: Mefenamic acid & Hydroxyl radical.read more
Citations
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The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals.
TL;DR: It is suggested that the deoxyribose assay is a simple and cheap alternative to pulse radiolysis for determination of rate constants for reaction of most biological molecules with hydroxyl radicals.
Journal ArticleDOI
How to characterize a biological antioxidant.
TL;DR: A review of the pro-oxidant and anti-Oxidant properties of ascorbic acid that have been reported in the literature leads to the conclusion that this compound acts as an antioxidant in vivo under most circumstances.
Journal ArticleDOI
Molecular characterization of vulnibactin biosynthesis in Vibrio vulnificus indicates the existence of an alternative siderophore
Wenzhi Tan,Vivek Verma,Kwangjoon Jeong,Soo Young Kim,Che-Hun Jung,Shee Eun Lee,Joon Haeng Rhee +6 more
TL;DR: It is confirmed that vulnibactin is assembled of both 2, 3-DHBA and SA, and conversion of SA to 2, 4-dihydroxybenzoic acid in presence of hydrogen peroxide and growth profile of AMP ligase mutants suggest a plausible existence of yet unidentified alternative siderophore that may be composed solely of 2,3-DH BA.
Journal ArticleDOI
The antioxidant action of taurine, hypotaurine and their metabolic precursors.
TL;DR: It is concluded that cysteamine and hypotaurine are far more likely to act as antioxidants in vivo than is taurine, provided that they are present in sufficient concentration at sites of oxidant generation.
Journal ArticleDOI
Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent
A Puppo,Barry Halliwell +1 more
TL;DR: The ability of haemoglobin to generate not only this 'reactive species', but also OH.
References
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Journal ArticleDOI
Free radicals and inflammation: protection of synovial fluid by superoxide dismutase.
TL;DR: Since phagocytizing polymorphonuclear leukocytes produce superoxide radicals, this reac-tion is sutggested and shown to be quantitatively feasible as the ini vivo mechanism of synovial fluid degradation in anl inflamed joint.
Journal ArticleDOI
A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution
Michael Anbar,P. Neta +1 more
TL;DR: In this paper, a compilation of the available kinetic data on the reactivities of the primary species of radiolysis in aqueous solution is presented, covering hydrated electrons, hydrogen atoms and hydroxyl radicals.
Journal ArticleDOI
Radical-cations as reference chromogens in kinetic studies of ono-electron transfer reactions: pulse radiolysis studies of 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate)
TL;DR: In this paper, the absolute rate constants for these electron-transfer reactions have been determined by pulse radiolysis, and they suggest that ABTS+ is likely to prove a useful reference free radical, not only for the study of reactions in which a free radical is the electron acceptor, but also for reactions of organic radicals with sulphydryl compounds.
Journal ArticleDOI
Mechanism for irreversible self-deactivation of prostaglandin synthetase.
TL;DR: A mechanism has been devised which accounts for the self-deactivation phenomenon, the effect of phenol and methional, the disulfide at the active site, and the pathway of substrate oxygenation.
Journal ArticleDOI
The biology and pathology of oxygen radicals.
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: Production of O2- by activated neutrophils is clinically significant, since it is an important component of the bactericidal actions of these cells and the inflammatory process, and exerts an anti-inflammatory action that may be useful in managing inflammations.
Related Papers (5)
Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids
Martin Grootveld,Barry Halliwell +1 more