Journal ArticleDOI
Application of a canine 238Pu biokinetics/dosimetry model to human bioassay data.
TLDR
A canine model based on existing knowledge about organ retention of plutonium has been adapted for use with human excretion data and indicated that predictions of urinary excretion are most sensitive to changes in particle solubility and diameter and in the ratio of fragment:particle surface area.Abstract:
Associated with the use of 238Pu in thermoelectric power sources for space probes is the potential for human exposure, primarily by inhalation and most likely as 238PuO2. Several models have been developed for assessing the level of intake and predicting the resulting radiation dose following human exposure to 239Pu. However, there are indications that existing models do not adequately describe the disposition and dosimetry of 238Pu following human exposure. In this study, a canine model that accounts for these differences has been adapted for use with human excretion data. The model is based on existing knowledge about organ retention of plutonium. An analysis of the sensitivity of the model to changes in aerosol-associated properties indicated that predictions of urinary excretion are most sensitive to changes in particle solubility and diameter and in the ratio of fragment:particle surface area. Application of the model to urinary excretion data from seven workers exposed to a 238Pu ceramic aerosol gave estimated intakes of 390-8,200 Bq and associated initial pulmonary burdens of 80-1,700 Bq. The resulting 50-y dose commitments to critical organs per Bq of 238Pu intake were estimated to be 0.5 mSv for the thoracic region, 0.2 mSv for the liver, and 1 mSv for the bone surfaces.read more
Citations
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Age-dependent doses to members of the public from intake of radionuclides Part 4: Inhalation dose coefficients
Toxicological profile for plutonium
TL;DR: In this article, the authors present a discussion of the role of the Internet in the evolution of the internet and its role in the Internet, and propose a method to use the Internet as a means of information exchange.
Journal ArticleDOI
Influences of parameter uncertainties within the ICRP 66 respiratory tract model: particle deposition.
TL;DR: A systematic review of the deposition component within the ICRP 66 respiratory tract model was conducted in which probability density functions were assigned to all input parameters and particle deposition values for the various trial simulations were shown to be well described by lognormal probability distributions.
Journal ArticleDOI
ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4.
François Paquet,Michael Bailey,Richard W. Leggett,George Etherington,Eric Blanchardon,T. Smith,G. Ratia,D.R Melo,Timothy Fell,V. Berkovski,John Harrison +10 more
TL;DR: The 2007 Recommendations introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series and Publications 54, 68, and 78.
Journal ArticleDOI
Toxicity of inhaled plutonium dioxide in beagle dogs
Bruce A. Muggenburg,Raymond A. Guilmette,J. A. Mewhinney,Nancy A. Gillett,Joe L. Mauderly,William C. Griffith,J. H. Diel,Bobby R. Scott,Fletcher F. Hahn,Bruce B. Boecker +9 more
TL;DR: The biological effects of inhaled 238PuO2 over the life spans of 144 beagle dogs suggest that similar dose-related biological effects could be expected in humans accidentally exposed to 238PUO2.
References
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Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
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