Journal ArticleDOI
Arthroscopic second-generation autologous chondrocyte implantation: A prospective 7-year follow-up study
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TLDR
The analysis of this group of homogeneous patients, prospectively evaluated every year for 7 years, shows that this bioengineered approach with the proper indications may offer good and stable clinical results over time.Abstract:
Background: Regenerative techniques, such as autologous chondrocyte implantation (ACI), have emerged as a potential therapeutic option for the treatment of chondral lesions, aiming to recreate a hyaline-like tissue in the damaged articular surface. The clinical application of the regenerative approach is well documented for different types of scaffold but mostly with an evaluation of the clinical outcome at short-term follow-up.Purpose: This study was conducted to analyze the clinical outcome obtained with arthroscopic second-generation ACI up to 7 years’ follow-up, to assess the durability of the results, and understand its real potential over time.Study Design: Case series; Level of evidence, 4.Methods: Sixty-two consecutive patients, 48 men and 14 women with a mean age of 28.1 ± 11.4 years, affected by chondral lesions of the femoral condyles were enrolled and treated with arthroscopic implantation of the bioengineered tissue Hyalograft C. The average size of the defects was 2.5 ± 1.0 cm2. Patients wer...read more
Citations
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Journal ArticleDOI
Repair and tissue engineering techniques for articular cartilage
Eleftherios Makris,Andreas H. Gomoll,Konstantinos N. Malizos,Jerry C. Hu,Kyriacos A. Athanasiou +4 more
TL;DR: Current, widely used clinical repair techniques for resurfacing articular cartilage defects and a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular Cartilage are described.
Journal ArticleDOI
Management of articular cartilage defects of the knee.
TL;DR: Results from outcomes studies as well as prospective randomized clinical trials comparing treatment methods are reviewed, and current practice guidelines are summarized.
Journal ArticleDOI
Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration
TL;DR: Preclinical evidence supports the use of PRP injections that might promote a favourable environment for joint tissues healing, and many biological variables might influence the clinical outcome and have to be studied to optimize PRP injective treatment of cartilage degeneration and osteoarthritis.
Journal ArticleDOI
Autologous chondrocyte implantation in the knee: systematic review and economic evaluation.
Hema Mistry,Martin Connock,Joshua Pink,Deepson Shyangdan,Christine Clar,Pamela Royle,Rachel Court,Leela C Biant,Andrew J. Metcalfe,Norman Waugh +9 more
TL;DR: Economic modelling suggested that ACI was cost-effective compared with MF across a range of scenarios, and survival analysis suggests that long-term results are better with ACI than with MF.
Journal ArticleDOI
Comparison of Platelet-Rich Plasma Formulations for Cartilage Healing An in Vitro Study
Carola Cavallo,Giuseppe Filardo,Erminia Mariani,Elizaveta Kon,Maurilio Marcacci,Maria Teresa Pereira Ruiz,Andrea Facchini,Brunella Grigolo +7 more
TL;DR: L- PRP and P-PRP induced distinct effects on human articular chondrocytes in vitro, possibly because of differences in the concentrations of platelets, leukocytes, growth factors, and other bioactive molecules.
References
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Journal ArticleDOI
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
Journal ArticleDOI
Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.
Gunnar Knutsen,Lars Engebretsen,Tom C. Ludvigsen,Jon Olav Drogset,Torbjørn Grøntvedt,Eirik Solheim,Torbjørn Strand,Sally Roberts,Vidar Isaksen,Oddmund Johansen +9 more
TL;DR: There was no significant difference in macroscopic or histological results between the two treatment groups and no association between the histological findings and the clinical outcome at the two-year time-point.
Journal ArticleDOI
Outcomes of Microfracture for Traumatic Chondral Defects of the Knee: Average 11-Year Follow-up
J. Richard Steadman,Karen K. Briggs,Juan J. Rodrigo,Mininder S. Kocher,Thomas J. Gill,William G. Rodkey +5 more
TL;DR: Patients 45 years and younger who underwent the microfracture procedure for full-thickness chondral defects, without associated meniscus or ligament pathology, showed statistically significant improvement in function and indicated that they had less pain.
Journal ArticleDOI
Autologous Chondrocyte Transplantation Biomechanics and Long-Term Durability
TL;DR: Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years, compared with 2 years after the transplantation.
Journal ArticleDOI
Clinical Efficacy of the Microfracture Technique for Articular Cartilage Repair in the Knee An Evidence-Based Systematic Analysis
TL;DR: This systematic analysis shows that microfracture provides effective short-term functional improvement of knee function but insufficient data are available on its long-term results.