Journal ArticleDOI
Asbestos-related mesothelioma: Evidence for a threshold in animals and humans
E.B. Ilgren,K. Browne +1 more
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TLDR
A threshold for mesothelioma for the major asbestos fiber types becomes not only plausible but also very likely in view of the existence of a distinct background incidence of spontaneously occurring and non-asbestos-related mesoteliomas.Citations
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The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure
TL;DR: The exposure specific risk of mesothelioma from the three principal commercial asbestos types is broadly in the ratio 1:100:500 for chrysotile, amosite and crocidolite respectively, and a linear relationship remains arguable for pleural and lung tumours (but not or peritoneal tumours).
Journal ArticleDOI
Mesothelioma: cases associated with non-occupational and low dose exposures.
TL;DR: There is no evidence of a threshold level below which there is no risk of mesothelioma, and this "natural level" is probably much lower than the 1-2/million/year which has been often cited.
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Pleural Mesothelioma: Dose-Response Relation at Low Levels of Asbestos Exposure in a French Population-based Case-Control Study
Y Iwatsubo,Jean-Claude Pairon,C. Boutin,O. Menard,N. Massin,Denis Caillaud,E. Orlowski,F. Galateau-Salle,Jean Bignon,Patrick Brochard +9 more
TL;DR: A clear dose-response relation was observed with the cumulative exposure index and a significant excess of mesothelioma was observed for levels of cumulative exposure that were probably far below the limits adopted in most industrial countries during the 1980s.
Toxicological profile for asbestos
TL;DR: The Toxicological Profile for asbestos reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on asbestos that assesses the significance of toxicity data to human health.
References
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Journal ArticleDOI
Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province.
TL;DR: In a majority of cases of diffuse pleural mesothelioma, all but one have a probable exposure to crocidolite asbestos (Cape blue) in the Asbestos Hills which lie to the west of Kimberley in the north west of Cape Province.
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Relation of Particle Dimension to Carcinogenicity in Amphibole Asbestoses and Other Fibrous Minerals
Mearl F. Stanton,Maxwell Layard,Andrew Tegeris,Eliza Miller,Margaret T May,Elizabeth Morgan,Alroy Smith +6 more
TL;DR: In 72 experiments, durable minerals in the form of particles on respirable size and of wide chemical and structural varieties, were implanted in the pleurae of outbred female Osborne- Mendel rats, suggesting that the carcinogenicity of fibers depended on dimension and durability rather than on physicochemical properties.
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Mechanisms of Mesothelioma Induction With Asbestos and Fibrous Glass
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The Effects of the Inhalation of Asbestos in Rats
TL;DR: Two experiments in which SPF Wistar rats were exposed by inhalation to dust clouds of the UICC standard reference samples for periods of between one day and 2 years are described, finding a positive association between asbestosis and lung tumours.