Journal ArticleDOI
Assessing familial aggregation with an ordinal response
TLDR
In this article, a latent variable model is considered for the analysis of twin data with an ordinal response, where the underlying latent multivariate normally distributed variable is expressed in terms of genetic and environmental effects, and the variance components associated with these effects are estimated.Abstract:
A latent variable model is considered for the analysis of twin data with an ordinal response. The underlying latent multivariate normally distributed variable is expressed in terms of genetic and environmental effects, and the variance components associated with these effects are estimated. We illustrate this approach with analysis of the NHLBI Twin Study. Model assessment is ascertained by proposing a goodness-of-fit test for ordered categorical data. Extensions of this approach for the investigation of how genetic effects vary over time are discussed.read more
Citations
More filters
Journal Article
Human biochemical genetics
TL;DR: For the next few weeks the course is going to be exploring a field that’s actually older than classical population genetics, although the approach it’ll be taking to it involves the use of population genetic machinery.
Journal ArticleDOI
Methodology for Genetic Studies of Twins and Families
TL;DR: The saimie paper suggests how susceptible individuals could reduce their total intake of aluminium and suggests that although definite proof is still lacking, there is more than enough evidence to fuel further epidemiological investigation.
References
More filters
Book
Introduction to quantitative genetics
TL;DR: The genetic constitution of a population: Hardy-Weinberg equilibrium and changes in gene frequency: migration mutation, changes of variance, and heritability are studied.
Journal ArticleDOI
Longitudinal data analysis using generalized linear models
Kung Yee Liang,Scott L. Zeger +1 more
TL;DR: In this article, an extension of generalized linear models to the analysis of longitudinal data is proposed, which gives consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence.
Journal Article
Human biochemical genetics
TL;DR: For the next few weeks the course is going to be exploring a field that’s actually older than classical population genetics, although the approach it’ll be taking to it involves the use of population genetic machinery.
Book
Methodology for Genetic Studies of Twins and Families
Michael C. Neale,Lon R. Cardon +1 more
TL;DR: The LISREL Script for Rater Bias Model and Data for Simplex Model as mentioned in this paper is one of the most well-known models in the literature for gene expression analysis.
Journal ArticleDOI
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
TL;DR: A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error.
Related Papers (5)
Latent variables, measurement error and methods for analysing longitudinal binary and ordinal data.
Mari Palta,Chin-Yu Lin +1 more