Journal ArticleDOI
Association of intra-tumoral tumour-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio is an independent prognostic factor in non-small cell lung cancer.
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TLDR
Investigation of TILs and inflammation markers in with patients advanced stage NSCLC and the association of their levels with prognosis found the relationship between the two pronostic factors remains unclear.Abstract:
Background Studies suggest that tumour-infiltrating lymphocytes (TILs) and inflammation markers have independent roles in non-small cell lung cancer (NSCLC), but the relationship between the two pronostic factors remains unclear. In this study, we investigated TILs and inflammation markers in with patients advanced stage NSCLC and assessed the association of their levels with prognosis. Materials and methods TILs were evaluated by immunohistochemical staining for cluster of differentiation 3 (CD3) and cluster of differentiation 5 (CD5) and by hematoxylin and eosin staining for non-specific lymphocyte. We investigated the localisation pattern of TILs in advanced stage NSCLC. We divided all cases into two groups: TILs-high and TILs-low groups, by 75th percentile of the population of. In our study, inflammation markers were assessed by C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR). Results The results showed that the presence of intra-tumoral high CD3+ and low CD5+ were an independent prognostic factor for overall survival (respectively, P = 0.022 and P = 0.025). Moreover, the high NLR and serum high CRP levels were associated with poor survival (respectively, P = 0.008; P = 0.027). In multi-variate survival analysis, the high CD3+ , low CD5+ , high NLR, tumour node metastasis (TNM) stage, depth of tumour invasion and lymph node metastasis remained independent prognostic factors (respectively, P = 0.018, P = 0.020, P = 0.024, P = 0.038, P = 0.020 and P = 0.047).The high NLR was detected negative correlation with intra-tumoral CD3+ and positive correlation with intra-tumoral CD5+ (respectively, r = -0.623, P = 0.012; r = 0.628, P = 0.028). Conclusions This study is first report demonstrating the prognostic value of intra-tumoral low CD5+ with NSCLC. Increased CD3+ and low CD5+ was observed in patients with poor prognosis; the two molecules were correlated with NLR, suggesting that inflammation might be used as improve therapeutic efficacy to immunotherapy for advanced NSCLC.read more
Citations
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Journal ArticleDOI
Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils
TL;DR: It is demonstrated that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth and inhibits recruitment of neutrophils from peripheral blood into tumor tissues.
Journal ArticleDOI
Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma
Tomoya Sudo,Ryosuke Nishida,Akihiko Kawahara,Kouhei Saisho,Koshi Mimori,Akira Yamada,Atsuhi Mizoguchi,Kazutaka Kadoya,Satoru Matono,Naoki Mori,Toshiaki Tanaka,Yoshito Akagi +11 more
TL;DR: Tumor-infiltrating lymphocyte status is a strong predictor of good prognosis for ESCC patients and Uni- and multivariate analyses identified tumor depth and TIL status as independent prognostic factors for CSS.
Journal ArticleDOI
Post-treatment changes in hematological parameters predict response to nivolumab monotherapy in non-small cell lung cancer patients
Monica Khunger,Pradnya D. Patil,Arjun Khunger,Manshi Li,Bo Hu,Sagar Rakshit,Arnab Basu,Nathan A. Pennell,James P. Stevenson,Paul Elson,Tanmay S. Panchabhai,Vamsidhar Velcheti +11 more
TL;DR: Post-treatment ANC, ALC, AMC and NLR are independent prognostic factors in NSCLC patients treated with nivolumab and changes in NLR ratio can be an early biomarker for response in NSclC patients treating with n ivolumAB.
Journal ArticleDOI
Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis
TL;DR: PLR may be a significant biomarker in the prognosis of HCC in different BCLC stages and correlation between PLR and event occurrence was related to poor clinical event occurrence only among BclC-C patients, though obvious heterogeneity was observed in all different B CLC stages.
Journal ArticleDOI
Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing.
Nasibeh Vatankhah,Younes Jahangiri,Gregory J. Landry,Robert B. McLafferty,Nabil J. Alkayed,Gregory L. Moneta,Amir F. Azarbal +6 more
TL;DR: NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors, and is associated with higher odds of nonhealing.
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