Journal ArticleDOI
Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease
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The results generally support the previously reported association between C pneumoniae infection and coronary heart disease, and caution should be used in interpreting the basis for this association.Abstract:
Objective. —To evaluate the association between prior infection withChlamydia pneumoniae, as measured by IgG antibody, and coronary artery disease. Design. —A population-based, case-control study. Setting. —Group Health Cooperative of Puget Sound, a Seattle-based health maintenance organization. Participants. —Men 55 years of age and younger and women 65 years of age and younger. Cases (n=171) were members of Group Health Cooperative undergoing diagnostic coronary angiography who had at least one coronary artery lesion occupying 50% or more of the luminal diameter. The population controls (n=120) were Group Health Cooperative members without known coronary heart disease. Main Outcome Measure. —The adjusted odds ratio (OR) for coronary artery disease associated with priorCpneumoniaeinfection as measured by the presence of IgG antibody. Results. —After adjusting for age, gender, and calendar quarter of blood drawing, the OR for coronary artery disease associated with the presence of antibody was 2.6 (95% confidence interval, 1.4 to 4.8). The association was limited to cigarette smokers, in whom the OR was 3.5 (95% confidence interval, 1.7 to 7.0). Among never-smokers, the OR was 0.8 (95% confidence interval, 0.3 to 1.9). When cases and controls were restricted to those assayed concurrently, the adjusted OR (smokers and nonsmokers combined) was 4.2 (95% confidence interval, 1.8 to 10.0). Adjustment for serum cholesterol, hypertension, alcohol use, diabetes, and socioeconomic status did not change these results. Only a weak association was found when cases were compared with 63 subjects whose angiographic results were normal (OR, 1.2; 95% confidence interval, 0.6 to 2.2). Conclusions. —These results generally support the previously reported association betweenCpneumoniaeinfection and coronary heart disease. However, caution should be used in interpreting the basis for this association. (JAMA. 1992;268:68-72)read more
Citations
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
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Systemic Diseases Caused by Oral Infection
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References
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Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
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Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction.
Pekka Saikku,Pekka Saikku,Kimmo Mattila,Kimmo Mattila,Markku S. Nieminen,Markku S. Nieminen,Jussi K. Huttunen,Jussi K. Huttunen,Maija Leinonen,Maija Leinonen,M. R. Ekman,M. R. Ekman,P H Mäkelä,P H Mäkelä,Ville Valtonen,Ville Valtonen +15 more
TL;DR: Investigation for antibodies to a novel type of Chlamydia sp, TWAR, and to chlamydial lipopolysaccharide (LPS) group antigen found they could be a factor in the pathogenesis of cardiovascular diseases.
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Sampling Methods for Random Digit Dialing
TL;DR: A method of sample selection for household telephone interviewing via random digit dialing is developed which significantly reduces the cost of such surveys as compared to dialing numbers completely at random.
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Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study.
Pekka Saikku,M. Leinonen,L. Tenkanen,E Linnanmäki,M. R. Ekman,Vesa Manninen,Matti Mänttäri,M H Frick,J K Huttunen +8 more
TL;DR: The results suggest that chronic C. pneumoniae infection may be a significant risk factor for the development of coronary heart disease.