Journal ArticleDOI
Associations between the two serum proteins haptoglobin and transferrin and leukaemia.
TLDR
Haptoglobin and transferrin (TF) types were determined for 134 patients with leukaemia of the four most common types and indicated a significantly increased frequency of TF C1C1 amongLeukaemia patients compared with controls.Abstract:
Haptoglobin and transferrin (TF) types were determined for 134 patients with leukaemia of the four most common types: acute lymphocytic (ALL), chronic lymphocytic (CLL), acute myelocytic (AML) and chronic myelocytic leukaemia (CML). The phenotype HP1 was found to have an increased incidence in the total patient group due to an increased incidence in those with AML, ALL and CML compared with controls, but not in those with CLL. Although tests of association applied to each of the samples of the four common types of leukaemia produced no significant chi 2 values, they did indicate that the relative incidence (RI) was just under 2 for the groupings of the acute forms ALL and AML, the myelocytic forms AML and CML and for the combination of ALL, AML and CML, respectively. All these associations were statistically significant (p less than 0.05). Analysis of TF subtypes and leukaemia indicated a significantly increased frequency of TF C1C1 among leukaemia patients compared with controls (p less than 0.005). Analysis of the samples of each of the four common types suggested that while the RI was raised in all but ALL patients, the association was significant only in AML patients (p less than 0.05). However, when the two myelocytic types were combined the RI was 2.3 and the association was highly significant (p less than 0.005). No such association could be detected in the lymphocytic forms.read more
Citations
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Journal ArticleDOI
Biological and clinical significance of haptoglobin polymorphism in humans.
TL;DR: The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology and is explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis.
Journal ArticleDOI
The eosinophilias, including the idiopathic hypereosinophilic syndrome.
TL;DR: There is evidence to suggest that, in some patients, clonal T-cell populations are present and treatment of the idiopathic hypereosinophilic syndrome has been varied and has included steroids, hydroxyurea, interferon and Tcell agents, and chemotherapy.
Journal ArticleDOI
Circulating Haptoglobin Is an Independent Prognostic Factor in the Sera of Patients with Epithelial Ovarian Cancer
Changqing Zhao,Loganath Annamalai,Changfa Guo,Narasimhan Kothandaraman,Stephen C. L. Koh,Huoming Zhang,Arijit Biswas,Mahesh Choolani +7 more
TL;DR: Evidence is provided that preoperative serum levels of haptoglobin could serve as an independent prognostic factor in patients presenting with epithelial ovarian cancer.
Journal ArticleDOI
Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.
TL;DR: There is a wealth of evidence associating alterations in iron balance and in iron-regulatory systems with disease progression, but that many issues related to the direction of causality, mechanisms of action and sensitivity to pharmacological intervention remain to be elucidated.
Journal ArticleDOI
Polymorphism of human haptoglobin and its clinical importance
TL;DR: This article summarizes the available data on the structure and functions of HP and the possible effects of Hp polymorphism in a number of important human disorders.
References
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Journal ArticleDOI
On estimating the relation between blood group and disease.
TL;DR: The use of x is recommended instead of d as a criterion of differential incidence of disease in relation to blood group, and in all statistical computations it is best to transform x into its logarithm.
Journal ArticleDOI
Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.
Journal ArticleDOI
Starch gel electrophoresis in a discontinous system of buffers.
TL;DR: Working on the separated and eluted fractions of the toxin of Corynebacterium diphtheriae in tissue cultures and in animals indicated that the resolution of these proteins was not completely satisfactory in the buffer.
Journal ArticleDOI
Guidelines for human gene nomenclature.
TL;DR: With the recent publications of the complete human genomesequence there is an estimated total of 26,000–40,000 genes, as suggested by the International Human Genome Sequencing Consortium and Venter.