H
Huoming Zhang
Researcher at King Abdullah University of Science and Technology
Publications - 67
Citations - 2680
Huoming Zhang is an academic researcher from King Abdullah University of Science and Technology. The author has contributed to research in topics: Proteome & Mutant. The author has an hindex of 28, co-authored 61 publications receiving 2273 citations. Previous affiliations of Huoming Zhang include Agency for Science, Technology and Research & Hong Kong University of Science and Technology.
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Journal ArticleDOI
Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes
Jung Eun Park,Hon Sen Tan,Arnab Datta,Ruenn Chai Lai,Huoming Zhang,Wei Meng,Sai Kiang Lim,Siu Kwan Sze +7 more
TL;DR: In this article, the authors observed that tumor cells produce a secretion that modifies their microenvironment to facilitate tumor angiogenesis and metastasis under hypoxia, and the secreted proteins were predominantly cytoplasmic and membrane proteins.
Journal ArticleDOI
Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.
Sudarsanareddy Lokireddy,Craig McFarlane,Xiaojia Ge,Huoming Zhang,Siu Kwan Sze,Mridula Sharma,Ravi Kambadur,Ravi Kambadur +7 more
TL;DR: It is demonstrated that myostatin signals through Smad3 (mothers against decapentaplegic homolog 3) to activate forkhead box O1 and Atrogin-1 expression, which further promotes the ubiquitination and subsequent proteasome-mediated degradation of critical sarcomeric proteins.
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Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events
Dominique P.V. de Kleijn,Frans L. Moll,W.E. Hellings,Gonen Ozsarlak-Sozer,Peter C. de Bruin,Pieter A. Doevendans,Aryan Vink,Louise M. Catanzariti,Arjan H. Schoneveld,Ale Algra,Mat J.A.P. Daemen,Erik A.L. Biessen,W. de Jager,Huoming Zhang,Jean-Paul P.M. de Vries,Erling Falk,Sai Kiang Lim,Peter J. van der Spek,Siu Kwan Sze,Gerard Pasterkamp +19 more
TL;DR: Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories and are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease.
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Simultaneous Characterization of Glyco- and Phosphoproteomes of Mouse Brain Membrane Proteome with Electrostatic Repulsion Hydrophilic Interaction Chromatography
Huoming Zhang,Tiannan Guo,Xin Li,Arnab Datta,Jung Eun Park,Jie Yang,Sai Kiang Lim,James P. Tam,Siu Kwan Sze +8 more
TL;DR: An optimized protocol using electrostatic repulsion hydrophilic interaction chromatography for the simultaneous enrichment of glyco- and phosphopeptides from mouse brain membrane protein digest is reported here to study the complex interaction of two different post-translational modifications in health and disease without being affected by interexperimental variations.
Journal ArticleDOI
Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods.
Changqing Zhao,Huoming Zhang,Wing-Cheong Wong,Xiaohui Sem,Hao Han,Siew-Min Ong,Yann-Chong Tan,Wei-Hseun Yeap,Chee-Sian Gan,Kok-Quan Ng,Mickey Koh,Philippe Kourilsky,Siu Kwan Sze,Siew Cheng Wong +13 more
TL;DR: Novel functional differences between the monocyte subsets are uncovered from differences in gene expression at the protein and mRNA levels, which would provide new insights into the different roles of the two monocytes subsets in regulating innate and adaptive immune responses.