Asymmetric Total Synthesis of Erythromycin. 1. Synthesis of an Erythronolide A Seco Acid Derivative via Asymmetric Induction

TLDR: The specific incorporation per C4 unit, 3.3%, calculated from 13C NMR data (Table I), is identical with that obtained from I4C radioactivity measurements.

Abstract: 3210-3213 The specific incorporation per C4 unit, 3.3%, calculated from 13C NMR data (Table I), is identical with that obtained from I4C radioactivity measurements. The signals due to the I3C-enriched carbon atoms in the proton decoupled I3C NMR spectrum of labeled retronecine appear as multiplets (Table