Journal ArticleDOI
Attenuation of endotoxin lung injury and prostanoid release by repeated endotoxin infusions in the adult sheep
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TLDR
It is concluded that with repeated endotoxemias, the pulmonary response is markedly attenuated, as is the prostanoid release, and a modest pulmonary hypertension and increase in plasma TxB 2 persists after endotoxin is discontinued.About:
This article is published in Journal of Critical Care.The article was published on 1986-12-01. It has received 2 citations till now. The article focuses on the topics: Lung injury & Lymph.read more
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Journal ArticleDOI
Long-term feed intake regulation in sheep is mediated by opioid receptors
TL;DR: It is indicated that SD33 increases feed intake in sheep after i.v. injection, and its effects are mediated via opioid receptors, however, the LPS-induced suppression in feed intake cannot be overcome by the opioid receptor ligand, SD33.
Journal ArticleDOI
Effect of thermal injury on endotoxin-induced lung injury
TL;DR: In this paper, the effects of a burn injury on the response of the lung to endotoxin were studied, and the authors concluded that the lung is more sensitive to the endotoxin after burn, probably as a result of an increased release of products of arachidonic acid metabolism and products of leukocyte activation caused by the body burn.
References
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Journal ArticleDOI
Sepsis and septic shock—A review of laboratory models and a proposal
TL;DR: Previously used models of sepsis such as the administration of endotoxin, intravenous infusion of live organisms, theadministration of fecal material into the peritoneal cavity, the placement of infected foreignMaterial into the soft tissues of the extremity, and surgical operations that partially destroy the normal barriers of the gastrointestinal tract are reviewed.
Journal ArticleDOI
Gram-negative bacteremia: IV. Re-evaluation of clinical features and treatment in 612 patients
TL;DR: Age, underlying host disease, granulocytopenia, congestive heart failure, diabetes mellitus, renal insufficiency, nosocomial infections, and antecedent treatment with antibiotics, corticosteroids, and antimetabolites significantly increased fatality rates.
Journal ArticleDOI
Multiple-organ failure. Generalized autodestructive inflammation?
TL;DR: It is concluded that sepsis is probably not the essential cause of MOF, and an alternative hypothesis is presented involving massive activation of inflammatory mediators by severe tissue trauma or intra-abdominal sepsi, resulting in systemic damage to vascular endothelia, permeability edema, and impaired oxygen availability to the mitochondria despite adequate arterial oxygen transport.
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Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome
TL;DR: Vigorous evaluation and treatment of infection in patients with the adult respiratory distress syndrome may improve survival and be more common in infected patients than noninfected patients.
Journal ArticleDOI
Measurement of Pulmonary Edema
TL;DR: The isotope transit time method is concluded that the edema water is determined more accurately when pulmonary edema is due to elevated pulmonary venous pressure than when due to increased vascular permeability.
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