Journal ArticleDOI
Sepsis and septic shock—A review of laboratory models and a proposal
TLDR
Previously used models of sepsis such as the administration of endotoxin, intravenous infusion of live organisms, theadministration of fecal material into the peritoneal cavity, the placement of infected foreignMaterial into the soft tissues of the extremity, and surgical operations that partially destroy the normal barriers of the gastrointestinal tract are reviewed.About:
This article is published in Journal of Surgical Research.The article was published on 1980-08-01. It has received 1414 citations till now. The article focuses on the topics: Sepsis & Septic shock.read more
Citations
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Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
TL;DR: A 2-day consensus conference on acute renal failure (ARF) in critically ill patients was organized by ADQI as discussed by the authors, where the authors sought to review the available evidence, make recommendations and delineate key questions for future studies.
Journal ArticleDOI
Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
Journal ArticleDOI
Hepatic platelet and leukocyte adherence during endotoxemia
Roland S. Croner,Elfie Hoerer,Yakup Kulu,Tilo Hackert,Martha-Maria Gebhard,Christian Herfarth,Ernst Klar +6 more
TL;DR: Hepatic platelet-endothelial interaction is an early event during endotoxemia, which underlines the probable involvement of platelets in leukocyte recruitment and makes the existence of autoregulatory liver mechanisms likely.
Journal ArticleDOI
The cardiovascular response of normal humans to the administration of endotoxin
Anthony F. Suffredini,Robert E. Fromm,Margaret M. Parker,Matthew Brenner,Joseph A. Kovacs,Robert Wesley,Joseph E. Parrillo +6 more
TL;DR: It is concluded that the administration of endotoxin to normal subjects causes a depression ofleft ventricular function that is independent of changes in left ventricular volume or vascular resistance, and suggests that endotoxin is a major mediator of the cardiovascular dysfunction in this condition.
Journal ArticleDOI
Cecal ligation and puncture.
William J. Hubbard,Mashkoor A. Choudhry,Martin G. Schwacha,Jeffrey D. Kerby,Loring W. Rue,Kirby I. Bland,Irshad H. Chaudry,Irshad H. Chaudry +7 more
TL;DR: The model of cecal ligation and puncture in rodents has been used extensively to investigate the clinical settings of sepsis and septic shock and is highly versatile in adapting to a range of severity and testing objectives.
References
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Journal Article
Multiple organ failure.
B Eiseman,R Beart,L Norton +2 more
TL;DR: Scientific, social, moral, ethical and legal factors emphasize the need to establish a statistically valid large data base concerning this new man-made syndrome which has both important scientific and social implications and this study is a first step in this direction.
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Multiple, progressive, or sequential systems failure. A syndrome of the 1970s.
TL;DR: As the care of injured patients has evolved and improved, various organ systems have in turn been the limiting factor affecting recovery after a severe injury or major operation.
Journal ArticleDOI
Microbial synergy in experimental intra-abdominal abscess.
Andrew B. Onderdonk,John G. Bartlett,Thomas J. Louie,Nadine Sullivan-Seigler,Sherwood L. Gorbach +4 more
TL;DR: The results suggest that intra-abdominal abscess formation is related to synergy between anaerobes and facultative bacteria, as well as the combination of an anaerobe and a facultative organism.
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Patterns of septic shock in man--a detailed study of 56 patients.
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Effect of sepsis on tissue adenine nucleotide levels.
TL;DR: The changes in adenine nucleotides observed in late sepsis (lpw-flow septic rats) are similar to those seen during early hemorrhagic shock and suggest inadequate perfusion associated with peritonitis as the cause.