Axon voltage-clamp simulations. A multicellular preparation.
TLDR
It is concluded that, in a multicellular preparation with series resistance, the recording of a square voltage pulse does not indicate voltage control of the transmembrane potential and the presence of a shunt pathway produces inaccurate values of current density.About:
This article is published in Biophysical Journal.The article was published on 1975-01-01 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Voltage clamp & Voltage drop.read more
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A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.
TL;DR: The activation and inactivation kinetics of the slow inward current were explored in detail and related to the plateau of the action potential.
Journal ArticleDOI
An improved vaseline gap voltage clamp for skeletal muscle fibers.
Bertil Hille,Donald T. Campbell +1 more
TL;DR: Comparison of recorded currents with simulations shows that while the transverse tubular system has regenerative sodium currents, they are too small to make important errors in the total current recorded at the surface under voltage clamp at low temperature.
Journal ArticleDOI
Calcium currents of isolated bovine ventricular myocytes are fast and of large amplitude.
Gerrit Isenberg,Udo Klöckner +1 more
TL;DR: A two microelectrode voltage clamp technique was applied to ventricular myocytes superfused with Tyrode solution and the steady-state activation curve was estimated, indicating an “apparent” reversal potential (Erev) but also masking ofICa by a transient outward current.
Journal ArticleDOI
Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres.
TL;DR: It is concluded that the approach described is valid for measurements of sodium currents in the potential range where action potentials are initiated, making it possible to study cardiac sodium channels in an adult mammalian preparation which is free of enzymatic treatment.
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