B-type natriuretic peptide predicts sudden death in patients with chronic heart failure
Rudolf Berger,Martin Huelsman,Karin Strecker,Anja Bojic,Petra Moser,Brigitte Stanek,Richard Pacher +6 more
TLDR
BNP levels are a strong, independent predictor of sudden death in patients with CHF, and Kaplan-Meier sudden death–free survival rates were significantly higher in patients below (99%) compared with patients above (81%) this cutoff point.Abstract:
Background— Given the high incidence of sudden death in patients with chronic heart failure (CHF) and the efficacy of implantable cardioverter-defibrillators, an appropriate tool for the prediction of sudden death is desirable. B-type natriuretic peptide (BNP) has prognostic significance in CHF, and the stimuli for its production cause electrophysiological abnormalities. This study tests BNP levels as a predictor of sudden death. Methods and Results— BNP levels, in addition to other neurohormonal, clinical, and hemodynamic variables, were obtained from 452 patients with a left ventricular ejection fraction (LVEF) ≤35%. For prediction of sudden death, only survivors without heart transplantation (HTx) or a mechanical assist device and patients who died suddenly were analyzed. Up to 3 years, 293 patients survived without HTx or a mechanical assist device, 89 patients died, and 65 patients underwent HTx. Mode of death was sudden in 44 patients (49%), whereas 31 patients (35%) had pump failure and 14 patients...read more
Citations
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Journal ArticleDOI
2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Mark H. Drazner,Gregg C. Fonarow,Stephen A. Geraci,Tamara B. Horwich,James L. Januzzi,Maryl R. Johnson,Edward K. Kasper,Wayne C. Levy,Frederick A. Masoudi,Patrick E. McBride,John J.V. McMurray,Judith E. Mitchell,Pamela N. Peterson,Barbara Riegel,Flora Sam,Lynne W. Stevenson,W.H. Wilson Tang,Emily J. Tsai,Bruce L. Wilkoff +23 more
TL;DR: In this article, Anderson et al. proposed a new FAHA Chair, Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect, Alice K. Jacobs et al., this article and Biykem Bozkurt.
Journal ArticleDOI
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Monica Colvin,Mark H. Drazner,Gerasimos Filippatos,Gregg C. Fonarow,Michael M. Givertz,Steven M. Hollenberg,JoAnn Lindenfeld,Frederick A. Masoudi,Patrick E. McBride,Pamela N. Peterson,Lynne W. Stevenson,Cheryl Westlake +16 more
TL;DR: The next generation of leaders in the field of FACC/FAHA education and training will be shaped by the experiences of the past 50 years, which will help shape the future of the profession.
Journal ArticleDOI
2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Mark H. Drazner,Gregg C. Fonarow,Stephen A. Geraci,Tamara B. Horwich,James L. Januzzi,Maryl R. Johnson,Edward K. Kasper,Wayne C. Levy,Frederick A. Masoudi,Patrick E. McBride,John J.V. McMurray,Judith E. Mitchell,Pamela N. Peterson,Barbara Riegel,Flora Sam,Lynne W. Stevenson,W.H. Wilson Tang,Emily J. Tsai,Bruce L. Wilkoff +23 more
TL;DR: The medical profession should play a central role in evaluating the evidence related to drugs, according to a report by the World Health Organization and the European Medicines Agency.
Journal ArticleDOI
Cardiovascular Risk Factors and Excess Adiposity Among Overweight Children and Adolescents: The Bogalusa Heart Study
TL;DR: The 99th P of BMI-for-age may be appropriate for identifying children who are at very high risk for biochemical abnormalities and severe adult obesity.
Journal ArticleDOI
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Monica Colvin,Mark H. Drazner,Gerasimos Filippatos,Gregg C. Fonarow,Michael M. Givertz,Steven M. Hollenberg,JoAnn Lindenfeld,Frederick A. Masoudi,Patrick E. McBride,Pamela N. Peterson,Lynne W. Stevenson,Cheryl Westlake +16 more
TL;DR: Biykem Bozkurt, MD, PHD, FACC, FAHA*y Javed Butler,MD, MBA, MPH, F ACC,FAHA*z Donald E. Casey, JR, MD; Monica M.Casey, JR; and Cheryl Westlake,PHD, RN, ACNS-BC, FAha, FHFSA.
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Richard W. Troughton,Chris Frampton,Timothy G. Yandle,Eric A Espine,M. Gary Nicholls,A. Mark Richards +5 more
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Theresa McDonagh,SD Robb,Murdoch,James J. Morton,Ian Ford,Caroline Morrison,H Tunstall-Pedoe,Jjv McMurray,H. J. Dargie +8 more
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Journal ArticleDOI
Attenuation of Compensation of Endogenous Cardiac Natriuretic Peptide System in Chronic Heart Failure Prognostic Role of Plasma Brain Natriuretic Peptide Concentration in Patients With Chronic Symptomatic Left Ventricular Dysfunction
Takayoshi Tsutamoto,Atsuyuki Wada,Keiko Maeda,Tomoko Hisanaga,Yukiharu Maeda,Daisuke Fukai,Masato Ohnishi,Yoshihisa Sugimoto,Masahiko Kinoshita +8 more
TL;DR: It is indicated that plasma BNP is more useful than ANP for assessing the mortality in patients with chronic CHF and that the plasma levels of BNP provide prognostic information independent of other variables previously associated with a poor prognosis.
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