Journal ArticleDOI
Bafilomycin A1 is a potent inhibitor of urine formation by Malpighian tubules of Drosophila hydei: Is a vacuolar-type ATPase involved in ion and fluid secretion?
TLDR
Considering the different effects of bafilomycin and vanadate on fluid and ion secretion a new working hypothesis for a transport model is proposed.About:
This article is published in Journal of Insect Physiology.The article was published on 1991-01-01. It has received 80 citations till now. The article focuses on the topics: Bafilomycin & Vanadate.read more
Citations
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Journal ArticleDOI
A vacuolar-type proton pump energizes K+/H+ antiport in an animal plasma membrane.
TL;DR: It is demonstrated that a vacuolar-type H(+)-ATPase energizes secondary active transport in an insect plasma membrane and thus it provides an alternative to the classical concept of plasma membrane energization in animal cells by the Na+/K(+)/H+ ATPase.
Journal ArticleDOI
The malpighian tubules of Drosophila melanogaster: a novel phenotype for studies of fluid secretion and its control.
TL;DR: The feasibility of adapting the established tubule secretion assay to the study of tubules of larval and adult Drosophila melanogaster is investigated and it is demonstrated that these Malpighian tubules, to extend studies of ion transport beyond that revealed by the techniques of classical physiology, are suitable.
Book ChapterDOI
Insect diuretic and antidiuretic hormones
TL;DR: Consideration is given to the evidence for diuretic and antidiuretic factors functioning as circulating neurohormones to regulate Malpighian tubule secretion and hindgut reabsorption in vivo and to how their activities are integrated for the maintenance of haemolymph volume and composition.
Journal ArticleDOI
INSECT MALPIGHIAN TUBULES: V-ATPase ACTION IN ION AND FLUID TRANSPORT.
TL;DR: Insect Malpighian tubules secrete fluid into the lumen as part of their function as excretory organs, and treatments that selectively slow cation transport across the epithelium cause the secreted fluid to become alkaline, whereas those that selectively reduce the rate of anion passage lead to secretion of acid fluid.
Functional domains are specified to single-cell resolution in a Drosophila epithelium (Malpighian tubuleyP-elementyepithelial physiologyygene expressionyenhancer trap)
TL;DR: The Malpighian tubule of Drosophila melanogaster is a simple epithe- lium that proliferates under the direction of a single tip cell into three morphologically distinct domains as discussed by the authors.
References
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Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.
Journal ArticleDOI
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.
TL;DR: It is concluded that bafilomycin A1 is a valuable tool for distinguishing among the three different types of ATPases and represents the first relatively specific potent inhibitor of vacuolar ATPases.
Journal Article
The action of cardiac glycosides on ion movements
TL;DR: It is difficult to summarise when so much that has been said is tentative but it is probably fair to state that it is doubtful whether therapeutic doses of cardiac glycosides cause appreciable lowering of the internal potassium concentration.
Journal ArticleDOI
The evolution of H+-ATPases
Nathan Nelson,Lincoln Taiz +1 more
TL;DR: Comparisons of the structure and properties of the V-ATPases with those of prokaryotic plasma membrane H +- ATPases are now providing unexpec- ted insights into the possible origin of the eukaryotic host cell.