Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents.
Michael Davidson,Abraham Reichenberg,Jonathan Rabinowitz,Mark Weiser,Zeev Kaplan,Mordehai Mark +5 more
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TLDR
It is demonstrated that simple assessment tools can predict predisposition to schizophrenia in healthy male adolescents and the model's predictive ability does not change as a function of the time elapsed between testing and first hospitalization, suggesting that the model identifies apparently healthy individuals who will manifest the disease later who are not prodromal to psychosis.Abstract:
OBJECTIVE: Subtle behavioral and intellectual abnormalities are often present in apparently healthy adolescents who later develop schizophrenia. The authors investigated whether these abnormalities can predict vulnerability for schizophrenia before the first psychotic manifestation. METHOD: The study consisted of linking the Israeli Draft Board Registry with the National Psychiatric Hospitalization Case Registry. The draft board tests measure intelligence, social functioning, organizational ability, interest in physical activity, and individual autonomy. Patients (N=509) were compared to nonpatients, i.e., adolescents not appearing in the National Psychiatric Registry (N=9,215), matched to patients by age, gender, and school attended at time of testing. RESULTS: Healthy male adolescents who were later hospitalized for schizophrenia had significantly lower test scores on all measures than adolescents not reported to the National Psychiatric Registry. The strongest predictors for schizophrenia were deficits...read more
Citations
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Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
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The Functional Significance of Social Cognition in Schizophrenia: A Review
TL;DR: The relationship between social cognition and functional outcome depends on the specific domains of each construct examined; however, it can generally be concluded that there are clear and consistent relationships between aspects of functional outcome and social cognition.
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Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study.
Richie Poulton,Avshalom Caspi,Terrie E. Moffitt,Mary Cannon,Robin M. Murray,HonaLee Harrington +5 more
TL;DR: These findings provide the first evidence for continuity of psychotic symptoms from childhood to adulthood, and the link between child and adult psychotic symptoms was not the result of general childhood psychopathology.
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Schizophrenia as a Disorder of Neurodevelopment
David A. Lewis,Pat Levitt +1 more
TL;DR: These findings suggest that combinatorial genetic and environmental factors, which disturb a normal developmental course early in life, result in molecular and histogenic responses that cumulatively lead to different developmental trajectories and the clinical phenotype recognized as schizophrenia.
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A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology.
John J. McGrath,John J. McGrath,Sukanta Saha,Joy Welham,Ossama El Saadi,Clare MacCauley,David Chant,David Chant +7 more
TL;DR: The width and skew of the rate distribution, and the significant impact of sex, urbanicity and migrant status on these distributions, indicate substantial variations in the incidence of schizophrenia.
References
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TL;DR: In this Section: 1. Multivariate Statistics: Why? and 2. A Guide to Statistical Techniques: Using the Book Research Questions and Associated Techniques.
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Applied Logistic Regression
David W. Hosmer,Stanley Lemeshow +1 more
TL;DR: Hosmer and Lemeshow as discussed by the authors provide an accessible introduction to the logistic regression model while incorporating advances of the last decade, including a variety of software packages for the analysis of data sets.
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Implications of normal brain development for the pathogenesis of schizophrenia
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TL;DR: The preface to the Second Edition Acknowledgments describes the background work, methodology, and results that were published in the first edition of this book, which focused on logistic Regression.