Journal ArticleDOI
Binding of radioactive N-hydroxy-acetylaminofluorene to synthetic polyribonucleotides
Fernando Marroquin,Ninel Coyote +1 more
Reads0
Chats0
About:
This article is published in Chemico-Biological Interactions.The article was published on 1970-08-01. It has received 13 citations till now. The article focuses on the topics: Acetylaminofluorene & Polyribonucleotides.read more
Citations
More filters
Book ChapterDOI
Chapter 8 – CELL PROLIFERATION AND EXPERIMENTAL LIVER CANCER
TL;DR: There is evidence in a number of cases that cell replication alters neither the metabolism of the carcinogen, nor the nature, extent or persistence of the binding of the activated carcinogen to macromolecules.
Journal ArticleDOI
Computer-assisted mechanistic structure-activity studies: application to diverse classes of chemical carcinogens.
TL;DR: This computer-assisted approach has been used to identify and calculate causally related molecular indicators of relative carcinogenic activity in five classes of chemical carcinogens: polycyclic aromatic hydrocarbons and their methyl derivatives, aromatic amines, chloroethanes,chloroalkenes and dialkyl nitrosamines.
Journal ArticleDOI
Interaction of the carcinogen N-acetoxy-N-2-acetylaminofluorene with polyadenylic acid: dependence of reactivity on conformation
E. Kriek,Joke Reitsema +1 more
Journal ArticleDOI
Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides.
TL;DR: If ionic strength was adjusted so that the two guanine-containing polymers showed equal thermal stability (as judged by Tm) then the alternating copolymer was 7 times as reactive as the homopolymer.
References
More filters
Book ChapterDOI
The metabolic activation of carcinogenic aromatic amines and amides.
Journal ArticleDOI
Enzyme-Catalyzed Reactions of the Carcinogen N-Hydroxy-2-fluorenylacetamide with Nucleic Acid
C. M. King,B. Phillips +1 more
TL;DR: A protein fraction obtained by gel filtration of a 105,000g supernatant of rat liver catalyzes three reactions of the hepatocarcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid.
Journal ArticleDOI
Sulfotransferase activation of N-hydroxy-2-acetylaminofluorene in rodent livers susceptible and resistant to this carcinogen.
TL;DR: It is found that the soluble fractions from the livers of female rats and four male rodent species resistant to hepatocarcinogenesis by N-hydroxy-AAF have lower capacities to transfer sulfate from PAPS to N- Hydroxy-AAF than do the soluble fraction of male rat livers.
Journal Article
The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo.
TL;DR: The data obtained offer further support for the suggestion that N -HO-AAF is a proximate carcinogen of AAF and are compatible with the hypothesis that interaction of AAAF and N - HO-AAF with protein and RNA may play some role in the molecular events leading to liver cancer.
Related Papers (5)
Further studies on the alkylation of nucleic acids and their constituent nucleotides
P. D. Lawley,P. Brookes +1 more