Open AccessJournal Article
Biological activities of Withania somnifera
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TLDR
The article reviews the scope of studies published in favor of anticancer potential of withaferin-A and discusses group of biologically active constituents known as withanolides, which are of under research potential as far treatment of cancer is concerned.Abstract:
Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders. From chemistry point of view, the drug contains group of biologically active constituents known as withanolides. The chemical structures of withanolides have been studied and they are widely distributed in family Solanacae. Withaferin- A is therapeutically active withanolide reported to be present in leaves. In animal studies, withaferin- A has shown significant anticancer activity. Majority of the anticancer drugs like Vinblastine, Vincristine, and Taxol have been derived from green flora. Today there is much interest in natural products with anticancer activity. Withanolides are of under research potential as far treatment of cancer is concerned. The article reviews the scope of studies published in favor of anticancer potential of withaferin-A.read more
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Pharmacologic overview of Withania somnifera, the Indian Ginseng
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Antimicrobial activity and probable mechanisms of action of medicinal plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus.
Peter Mwitari,Peter Mwitari,Peter Amwoga Ayeka,Peter Amwoga Ayeka,Joyce Ondicho,Esther N. Matu,Christine Bii +6 more
TL;DR: Investigation of organic extracts of Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus for treatment of microbial infections and cancer found both bactericidal and fungicidal activity and antimicrobial activity.