Journal ArticleDOI
Both L-DOPA and HFS-STN restore the enhanced group II spinal reflex excitation to a normal level in patients with Parkinson’s disease
Véronique Marchand-Pauvert,Angélique Gerdelat-Mas,F. Ory-Magne,F. Calvas,Dominique Mazevet,Sabine Meunier,Christine Brefel-Courbon,Marie Vidailhet,Marion Simonetta-Moreau +8 more
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TLDR
These results further support a group II contribution to the enhanced long latency response (LLR) to muscle stretch observed in wrist muscles of rigid Parkinson's disease patients.About:
This article is published in Clinical Neurophysiology.The article was published on 2011-05-01. It has received 16 citations till now. The article focuses on the topics: Deep brain stimulation.read more
Citations
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A common optimization principle for motor execution in healthy subjects and parkinsonian patients.
Pierre Baraduc,Pierre Baraduc,Stéphane Thobois,Jing Gan,Emmanuel Broussolle,Michel Desmurget,Michel Desmurget +6 more
TL;DR: It is suggested that constrained optimization of motor effort is the main determinant of movement planning (choice of speed) and movement production, in both healthy and PD subjects.
Journal ArticleDOI
Myometry revealed medication-induced decrease in resting skeletal muscle stiffness in Parkinson's disease patients.
TL;DR: Myometry revealed that anti-parkinsonian medication decreases not only rigidity in PD, but also rigidity-related stiffness in resting skeletal muscles in PD patients, showing that myometry can enrich neurological practice, by allowing objective and reliable assessment of parkinsonian rigidity treatment effectiveness.
Journal ArticleDOI
Interval training-induced alleviation of rigidity and hypertonia in patients with Parkinson's disease is accompanied by increased basal serum brain-derived neurotrophic factor.
Jarosław Marusiak,Ewa Żeligowska,Joanna Mencel,Katarzyna Kisiel-Sajewicz,Joanna Majerczak,Jerzy A. Zoladz,Artur Jaskólski,Anna Jaskólska +7 more
TL;DR: In this paper, the effects of cycloergometric interval training on parkinsonian rigidity, relaxed biceps brachii muscle tone in affected upper extremities, and serum level of brain-derived neurotrophic factor were examined.
Journal ArticleDOI
Primary motor cortex of the parkinsonian monkey: altered neuronal responses to muscle stretch
TL;DR: The results suggest that parkinsonism alters the timing and specificity of M1 responses to muscle stretch, consistent with the idea that the increase in LLSR gain that contributes to parkinsonian rigidity is localized to the spinal cord.
Journal ArticleDOI
Subthalamic nucleus stimulation reverses spinal motoneuron activity in parkinsonian patients.
Sylvie Raoul,Vincent Roualdes,Céline Deligny,Dominique Leduc,Jean-Charles Lamy,Alexandra Lackmy-Vallée,Jean-Paul Nguyen,Philippe Damier,R. Katz +8 more
TL;DR: The unexpected finding that changes in the rigidity score and the amount of homosynaptic depression are time-locked to the onset of deep brain stimulation leads the authors to reconsider the mechanisms underlying changes in homosyaptic depression.
References
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Journal ArticleDOI
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
W R Gibb,Andrew J. Lees +1 more
TL;DR: Associated pathological findings suggest that cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease.
Journal ArticleDOI
The pedunculopontine nucleus and Parkinson's disease
TL;DR: The anatomical connections and physiological attributes of the pedunculopontine nucleus are highlighted to discuss how the function of these connections may be altered in the parkinsonian state and to speculate how present and potential future therapy directed to the PPN might improve akinesia and gait difficulties in parkinsonia patients.
Journal ArticleDOI
Functional and pathophysiological models of the basal ganglia.
Thomas Wichmann,Mahlon R. DeLong +1 more
TL;DR: Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny and an update of these models is clearly timely.
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