Journal ArticleDOI
Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters.
TLDR
It was concluded that both soybean and kudzu phytoestrogens could modify favorably lipoprotein profiles in ovariectomized and castrated hamsters.Abstract:
The present study compared the hypolipidemic activity of kudzu phytoestrogens with that of soybean phytoestrogen in estrogen- and androgen-deficient hamsters. In the first experiment, ovariectomized hamsters (n = 37) were randomly divided into four groups (n = 9−10 each group). The first group was the control group, whereas the second group had the time-releasing estradiol-17β subcutaneous (pellet) implants as a positive control. The third and fourth groups were orally administered soybean or kudzu phytoestrogen extracts (30 mg/kg of body weight) per day. In the second experiments, the first group of male hamsters (n = 9) received a sham operation, whereas the other three groups of male hamsters (n = 9 each) were castrated. The castrated control group received orally distilled water, whereas the second and third castrated groups were orally given 30 mg/kg soybean or kudzu phytoestrogen extracts. The results for the first experiment showed that the ovariectomized hamsters orally given soybean and kudzu phy...read more
Citations
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Cholesterol-Lowering Nutraceuticals and Functional Foods
Zhen-Yu Chen,Rui Jiao,Ka Ying Ma +2 more
TL;DR: This review summarizes the findings of recent studies on the production, application, efficacy, and mechanisms of popular cholesterol-lowering nutraceuticals and functional foods.
Journal ArticleDOI
Nutraceuticals and Functional Foods in the Management of Hyperlipidemia
TL;DR: This review attempts to give an overview of lipid homeostasis and summarize recent findings of hypolipidemic nutraceuticals and functional foods according to their active ingredients, focusing on the efficacy and underlying mechanisms.
Journal ArticleDOI
Chromatographic profiling and multivariate analysis for screening and quantifying the contributions from individual components to the bioactive signature in natural products
Olav M. Kvalheim,Hoi Yan Chan,Iris F.F. Benzie,Yim Tong Savio Szeto,Yim Tong Savio Szeto,Alexander Hing Chung Tzang,Daniel K. W. Mok,Foo Tim Chau +7 more
TL;DR: A new approach for assigning bioactivity to individual components in extracts from natural products is presented and validated in this article, where 60 mixtures were created according to a uniform design from 12 chemical components of which 7 possessed antioxidant activity.
Journal ArticleDOI
Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females.
TL;DR: Several botanical compounds have been found to have beneficial effects in the treatment of the symptoms of menopause and other symptoms of aging, including CVD, cognitive decline, and metabolic diseases.
Journal ArticleDOI
Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats
Lai Ming Yung,Xiao Yu Tian,Wing Tak Wong,Fung Ping Leung,Lai Hang Yung,Zhen-Yu Chen,Chi Wai Lau,Paul M. Vanhoutte,Xiaoqiang Yao,Yu Huang +9 more
TL;DR: The novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles are demonstrated, providing insight into developing cranberry products into useful dietary supplements for postmenopausal women.
References
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Journal ArticleDOI
Soybean foods and their benefits: potential mechanisms of action.
Adetayo O. Omoni,Rotimi E. Aluko +1 more
TL;DR: This review will focus on some of the potential mechanisms whereby soybeans exert their protective effects against heart disease, cancer, and osteoporosis.
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Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants.
Aimin Chen,Walter J. Rogan +1 more
TL;DR: It is concluded that more clinical and epidemiological study is warranted of the effects on estrogen activity, immune function, and thyroid economy of genistein and daidzein, two isoflavones in soy infant formula, and existing human studies of soy formula use.
Journal ArticleDOI
Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms
Nica M. Borradaile,Nica M. Borradaile,Linda E. de Dreu,Lisa J. Wilcox,Lisa J. Wilcox,Jane Y. Edwards,Jane Y. Edwards,Murray W. Huff,Murray W. Huff +8 more
TL;DR: Results indicate that genistein and daidzein inhibit hepatocyte apoB secretion through several mechanisms, including inhibition of cholesterol synthesis and esterification, inhibition of MTP activity and expression and increased expression of the LDL-receptor.
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Soy Isoflavones Affect Sterol Regulatory Element Binding Proteins (SREBPs) and SREBP-Regulated Genes in HepG2 Cells
TL;DR: It is hypothesized that maturation of SREBP and induction of S RE-regulated genes produce an increase in surface LDL receptor expression that increases the clearance of plasma cholesterol, thus decreasing plasma cholesterol levels.
Journal ArticleDOI
Dietary phyto-oestrogens and bone health
TL;DR: The use of dietary phyto-oestrogens as a possible option for the prevention of osteoporosis has raised considerable interest, but the evidence in support of a bone-sparing effect in post-menopausal women is still not sufficiently convincing.