Journal ArticleDOI
Brief report: melatonin-related hypogonadotropic hypogonadism.
Manuel Puig-Domingo,Susan M. Webb,José Serrano,M. A. Peinado,Rosa Corcoy,Jordi Ruscalleda,Russel J. Reiter,Alberto de Leiva +7 more
TLDR
Melatonin profoundly influences reproductive function in seasonally breeding mammals, including the Syrian hamster, in which pinealectomy leads to sustained reproductive activity and in which appropriately timed injections of melatonin inhibit reproductive function.Citations
More filters
Journal ArticleDOI
The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration
Anne-Simone Parent,Grete Teilmann,Anders Juul,Niels E. Skakkebæk,Jorma Toppari,Jean-Pierre Bourguignon +5 more
TL;DR: These observations urge further study of the onset of puberty as a possible sensitive and early marker of the interactions between environmental conditions and genetic susceptibility that can influence physiological and pathological processes.
Journal ArticleDOI
Melatonin in humans.
TL;DR: This review summarizes current knowledge about melatonin in humans and its clinical implications and concludes that there is evidence that melatonin may have a role in the biologic regulation of circadian rhythms, sleep, mood, and perhaps reproduction, tumor growth, and aging.
Journal ArticleDOI
Melatonin rhythmicity: effect of age and Alzheimer's disease.
Debra J. Skene,Dick F. Swaab +1 more
TL;DR: Future research needs to pinpoint the site(s) of age-related dysfunction so that therapies can be specifically tailored to correct the abnormality in addition to reinforcing any of the intact processes.
Journal ArticleDOI
Melatonin and human reproduction
TL;DR: While correlations between melatonin and the status of the reproductive system in humans have been noted, whether they are functionally related remains to be determined.
Journal ArticleDOI
Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances
TL;DR: Oral melatonin therapy was used to treat severe circadian sleep‐wake disturbances in eight children and young adults in an open study, promising as an efficient and seemingly safe alternative for treatment of severe circadianSleep disturbances.
References
More filters
Journal ArticleDOI
Light Suppresses Melatonin Secretion in Humans
TL;DR: Findings establish that the human response to light is qualitatively similar to that of other mammals.
Journal ArticleDOI
The Pineal and Its Hormones in the Control of Reproduction in Mammals
TL;DR: By the usual criteria in endocrinology, the pineal now fulfills all the qualifications of an organ of internal secretion.
Journal ArticleDOI
Fall in nocturnal serum melatonin during prepuberty and pubescence
Franz Waldhauser,H. Frisch,M. Waldhauser,Gunther Weiszenbacher,Ulrike Zeitlhuber,Richard J. Wurtman +5 more
TL;DR: Nocturnal plasma concentrations of luteinising hormone measured at various stages of puberty tended to vary inversely with those of melatonin, and past difficulties in demonstrating a relation between gonadal maturation and human pineal function may have reflected the use of insufficiently sensitive or specific melatonin assays, or serum sampling only during daytime.
Journal ArticleDOI
The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women.
Amnon Brzezinski,Harry J. Lynch,Machelle M. Seibel,Meihua Deng,T. M. Nader,Richard J. Wurtman +5 more
TL;DR: The elevated plasma melatonin levels in women with hypothalamic amenorrhea suggest that the hormone may be involved in the neuroendocrine pathology underlying this disorder.
Journal ArticleDOI
Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea.
TL;DR: While daytime melatonin concentrations were nondetectable in both groups, the integrated nocturnal levels were 3-fold greater in HA (244 +/- 58 (SE) vs 74 +/- 32 pmol-min/Lx10(3), p less than 0.005).