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Brief review Atopic dermatitis: a review of topical treatment options
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TLDR
A multi-therapeutic approach that incorporates short-term management of flares and longer-term strategies to prolong the time between flares is needed for the treatment of AD.Abstract:
Background: Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease with a wide range of severity, and is usually the first manifestation of atopic disease. It is one of the most common skin disorders in developed countries, affecting approximately 20% of children and 1–3% of adults. Symptoms such as eczematous papules, plaques, and itch, and their associated consequences, such as sleep disturbance, can significantly impact the quality of life of the patient and family.read more
Citations
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Journal ArticleDOI
Atopic Dermatitis: Natural History, Diagnosis, and Treatment
TL;DR: An overview of the natural history, clinical features, and treatment of atopic dermatitis is given.
Journal ArticleDOI
Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis
Bodi Zhang,Konstantinos-Dionysios Alysandratos,Konstantinos-Dionysios Alysandratos,Asimenia Angelidou,Asimenia Angelidou,Shahrzad Asadi,Nikolaos Sismanopoulos,Danae A. Delivanis,Zuyi Weng,Alexandra Miniati,Alexandra Miniati,Magdalini Vasiadi,Magdalini Vasiadi,Alexandra Katsarou-Katsari,Benchun Miao,Susan E. Leeman,Dimitrios Kalogeromitros,Theoharis C. Theoharides +17 more
TL;DR: The role of mitochondrial dynamics in degranulation of human cultured mast cells requires mitochondrial dynamics, also implicated in AD, and mitochondrial translocation from a perinuclear location to exocytosis sites is evident.
Journal ArticleDOI
Pathophysiology and therapy of pruritus in allergic and atopic diseases
TL;DR: This work presents a novel and exciting new approach to the treatment of pruritus in allergic and atopic diseases with real-world implications for diagnosis and treatment of these diseases.
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The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review
TL;DR: The use of moisturizer is discussed both for skin health maintenance as well as a definitive or adjuvant therapy for many kinds of dermatitis.
Journal ArticleDOI
Barrier repair therapy in atopic dermatitis: an overview.
TL;DR: Some evidence that certain products had therapeutic efficacy in improving clinical and/or biophysical parameters of patients with AD is found, but study methods were often flawed and sample sizes were small.
References
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Journal ArticleDOI
Atopic dermatitis and the atopic march.
TL;DR: Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march, which has a tremendously negative effect on the quality of life of patients as well as family.
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Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood.
Hywel C Williams,Colin F. Robertson,Alistair Stewart,Nadia Aït-Khaled,Gabriel Anabwani,Ross Anderson,Innes Asher,Richard Beasley,Bengt Björkstén,Michael Leslie Burr,Tadd Clayton,Julian Crane,Philippa Ellwood,Ulrich Keil,Christopher K C Lai,Javier Mallol,Fernando D. Martinez,Edwin A. Mitchell,Stephen Montefort,Neil Pearce,Jayant Shah,Bonnie Sibbald,David P. Strachan,Erika von Mutius,Stephan K. Weiland +24 more
TL;DR: Symptoms of atopic eczema exhibit wide variations in prevalence both within and between countries inhabited by similar ethnic groups, suggesting that environmental factors may be critical in determining disease expression.
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Staphylococcus aureus in the lesions of atopic dermatitis
TL;DR: Systemic and topical antibiotic therapy pro‐duced a profound decrease in Staph.
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Topical corticosteroid phobia in patients with atopic eczema
TL;DR: The need for provision of better information and education to patients and possibly general practitioners regarding the safety, potency and appropriate use of topical corticosteroids is highlighted.