Reference EntryDOI
Brown, Michael Stuart
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In this article, the molecular mechanisms of cholesterol synthesis and the clinical consequences of their abnormalities were elucidated with the help of molecular mechanisms and their effects on the human body's metabolism.Abstract:
1941– American scientist who, with Joseph Goldstein, elucidated the molecular mechanisms of cholesterol synthesis and the clinical consequences of their abnormalities.read more
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A receptor-mediated pathway for cholesterol homeostasis.
TL;DR: The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.