Journal ArticleDOI
Carbon disulfide intoxication from overdosage of disulfiram.
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TLDR
Clinical and experimental evidence bearing on the relationship between disulfiram and its metabolite, carbon disulfide, and similarities in the syndromes associated with the toxicity of each are reviewed.Abstract:
The author discusses a case of acute brain syndrome with depression, peripheral neuropathy, and transient parkinsonism following ingestion of large amounts of disulfiram. He reviews clinical and experimental evidence bearing on the relationship between disulfiram and its metabolite, carbon disulfide, and reviews similarities in the syndromes associated with the toxicity of each.read more
Citations
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Peripheral Neuropathy Caused by Chemical Agents
TL;DR: In this article, the authors discuss peripheral neuropathy caused by chemical agents and propose a method to diagnose peripheral neuropathies caused by Chemical Agents, which they call Peripheral Neuropathy Caused by Chemical Agent (PNCA).
Journal ArticleDOI
A Critical Review of the Literature on Carbon Disulfide Toxicity
TL;DR: A critical review of the literature on carbon disulfide toxicity can be found in this article, with a focus on Carbon Disulfide Toxicity (CDT) as a potential carcinogen.
Journal ArticleDOI
Disulfiram toxicity and carbon disulfide poisoning
TL;DR: The results suggest that carbon disulfide is responsible for the behavioral and neurological side effects of disulfiram, and individuals receiving as little as 125 mg of dis sulfuriram per day may be at a three- to four-fold greater risk for arteriosclerotic cardiovascular disease than a comparable population not receiving the drug.
References
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Journal ArticleDOI
Biogenic Amines and Emotion
TL;DR: Although there does appear to be a fairly consistent relationship between the effects of pharmacological agents on norepinephrine metabolism and on affective state, a rigorous extrapolation from pharmacological studies to pathophysiology cannot be made, and confirmation of this hypothesis must ultimately depend upon direct demonstration of the biochemical abnormality in the naturally occurring illness.
Journal Article
The effect of disulfiram on catecholamine levels in the brain
TL;DR: In animals pretreated with the monoamine oxidase inhibitor pheniprazine, there was a closer correlation between the decrease in the norepinephrine content and the increase in the dopamine content in the hypothalamus and brainstem.
Journal ArticleDOI
Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites
TL;DR: Disulfiram has been shown to markedly inhibit dopamine-β-Hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting.
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