Journal ArticleDOI
CCN proteins: multifunctional signalling regulators.
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TLDR
The differential binding of CCN2 isoforms to LRP highlights the importance of functional interactions between individual modules, and reinforces the concept that different module combinations might confer agonistic or antagonistic activities.About:
This article is published in The Lancet.The article was published on 2004-01-03. It has received 671 citations till now. The article focuses on the topics: CCN protein & CTGF.read more
Citations
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Journal ArticleDOI
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
Michael Dews,Asal Homayouni,Duonan Yu,Danielle Murphy,Cinzia Sevignani,Erik A. Wentzel,Emma E. Furth,William M. F. Lee,Greg H. Enders,Joshua T. Mendell,Andrei Thomas-Tikhonenko +10 more
TL;DR: Findings establish a role for microRNAs in non–cell-autonomous Myc-induced tumor phenotypes and suggest that Ras-only cells with a miR-17-92–encoding retrovirus reduced Tsp1 and CTGF levels and formed larger, better-perfused tumors.
Journal ArticleDOI
miR-133 and miR-30 Regulate Connective Tissue Growth Factor Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling
Rudy F. J. J. Duisters,Anke J. Tijsen,Blanche Schroen,Joost J. Leenders,Viola Lentink,Ingeborg van der Made,Veronica Herias,Rick van Leeuwen,Mark W.M. Schellings,Paul Barenbrug,Jos G. Maessen,Stephane Heymans,Yigal M. Pinto,Esther E. Creemers +13 more
TL;DR: The results show that both miR-133 and mi-30 directly downregulate CTGF, a key profibrotic protein, and thereby establish an important role for these miRNAs in the control of structural changes in the extracellular matrix of the myocardium.
Journal ArticleDOI
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
TL;DR: Insulin resistance and lipotoxicity represent the missing links (beyond the classical cardiovascular risk factors) that help explain the accelerated rate of CVD in type 2 diabetic patients.
Journal ArticleDOI
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Florian Lang,Christoph Böhmer,Monica Palmada,Guiscard Seebohm,Nathalie Strutz-Seebohm,Volker Vallon +5 more
TL;DR: The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress and hormones, and may play an active role in a multitude of pathophysiological conditions.
Journal ArticleDOI
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
Andrew Leask,David Abraham +1 more
TL;DR: The CCN family of secreted proteins not only regulate crucial biological processes including cell differentiation, proliferation, adhesion, migration, apoptosis, ECM production, chondrogenesis and angiogenesis, but also have more sinister roles promoting conditions such as fibrogenesis.
References
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Journal ArticleDOI
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.
TL;DR: Results show that CTGF inhibits BMP and activates TGF-β signals by direct binding in the extracellular space and can antagonize BMP4 activity by preventing its binding to BMP receptors and has the opposite effect, enhancement of receptor binding, on T GF-β1.
Journal ArticleDOI
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
Sanja Ivkovic,Byeong S. Yoon,Steven N. Popoff,Fayez F. Safadi,Diana E. Libuda,Robert C. Stephenson,Aaron Daluiski,Karen M. Lyons +7 more
TL;DR: It is demonstrated that CTGF is important for cell proliferation and Matrix remodeling during chondrogenesis, and is a key regulator coupling extracellular matrix remodeling to angiogenesis at the growth plate.
Journal ArticleDOI
The CCN family of angiogenic regulators: the integrin connection.
Lester F. Lau,Stephen C.-T. Lam +1 more
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The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
TL;DR: This work focuses on the regulation of Cellular Functions by the CCN Family and the structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed family members.
Journal ArticleDOI
Connective Tissue Growth Factor: What's in a Name?
TL;DR: Connective tissue growth factor has emerged as a potential important effector molecule in both physiological and pathological processes and has provided a new target for therapeutic intervention in fibrotic diseases.
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All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
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The CCN family of angiogenic regulators: the integrin connection.
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