E
Erik A. Wentzel
Researcher at Johns Hopkins University
Publications - 12
Citations - 6830
Erik A. Wentzel is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 10, co-authored 12 publications receiving 6537 citations. Previous affiliations of Erik A. Wentzel include Howard Hughes Medical Institute & Nationwide Children's Hospital.
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Journal ArticleDOI
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Tsung Cheng Chang,Erik A. Wentzel,Oliver A. Kent,Kalyani Ramachandran,Michael Mullendore,Kwang Hyuck Lee,Georg Feldmann,Munekazu Yamakuchi,Marcella Ferlito,Charles J. Lowenstein,Dan E. Arking,Michael A. Beer,Anirban Maitra,Joshua T. Mendell +13 more
TL;DR: It is demonstrated that microRNAs (miRNAs) are important components of the p53 transcriptional network and miR-34a-responsive genes are highly enriched for those that regulate cell-cycle progression, apoptosis, DNA repair, and angiogenesis.
Journal ArticleDOI
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Janaiah Kota,Raghu R. Chivukula,Kathryn A. O'Donnell,Erik A. Wentzel,Chrystal L. Montgomery,Hun-Way Hwang,Tsung Cheng Chang,Perumal Vivekanandan,Michael Torbenson,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Joshua T. Mendell +13 more
TL;DR: It is demonstrated that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is normally expressed at high levels in diverse tissues that may provide a general strategy for miRNA replacement therapies.
Journal ArticleDOI
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
Michael Dews,Asal Homayouni,Duonan Yu,Danielle Murphy,Cinzia Sevignani,Erik A. Wentzel,Emma E. Furth,William M. F. Lee,Greg H. Enders,Joshua T. Mendell,Andrei Thomas-Tikhonenko +10 more
TL;DR: Findings establish a role for microRNAs in non–cell-autonomous Myc-induced tumor phenotypes and suggest that Ras-only cells with a miR-17-92–encoding retrovirus reduced Tsp1 and CTGF levels and formed larger, better-perfused tumors.
Journal ArticleDOI
A hexanucleotide element directs microRNA nuclear import.
TL;DR: The results indicate that miRNAs sharing common 5′ sequences, considered to be largely redundant, might have distinct functions because of the influence of cis-acting regulatory motifs.
Journal ArticleDOI
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
Tsung Cheng Chang,Lauren R Zeitels,Hun-Way Hwang,Raghu R. Chivukula,Erik A. Wentzel,Michael Dews,Jason J. Jung,Ping Gao,Chi V. Dang,Michael A. Beer,Andrei Thomas-Tikhonenko,Joshua T. Mendell +11 more
TL;DR: It is shown that Myc induces Lin-28B expression in multiple human and mouse tumor models and an orchestration of transcriptional and posttranscriptional mechanisms in Myc-mediated reprogramming of miRNA expression is uncovered.