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William M. F. Lee
Researcher at University of Pennsylvania
Publications - 46
Citations - 4764
William M. F. Lee is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 28, co-authored 46 publications receiving 4586 citations. Previous affiliations of William M. F. Lee include Wistar Institute & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
Michael Dews,Asal Homayouni,Duonan Yu,Danielle Murphy,Cinzia Sevignani,Erik A. Wentzel,Emma E. Furth,William M. F. Lee,Greg H. Enders,Joshua T. Mendell,Andrei Thomas-Tikhonenko +10 more
TL;DR: Findings establish a role for microRNAs in non–cell-autonomous Myc-induced tumor phenotypes and suggest that Ras-only cells with a miR-17-92–encoding retrovirus reduced Tsp1 and CTGF levels and formed larger, better-perfused tumors.
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Improved Automatic Detection and Segmentation of Cell Nuclei in Histopathology Images
TL;DR: This paper presents a robust and accurate novel method for segmenting cell nuclei using a combination of ideas, and presents an efficient semiautomated approach to editing automated segmentation results that requires two mouse clicks per operation.
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Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.
Christina M. Coughlin,Kevin E. Salhany,Maria Wysocka,Etsuko Aruga,Holly L. Kurzawa,Alfred E. Chang,Christopher A. Hunter,Jonathan C. Fox,Giorgio Trinchieri,William M. F. Lee,William M. F. Lee +10 more
TL;DR: In syngeneic A/J mice, SCK cells expressing mIL-12 or mil-18 were less tumorigenic and formed tumors more slowly than control cells, suggesting that anti-SCK immunity is unlikely to be responsible for protection, and angiogenesis inhibition appeared to be a property of both SCK.12 and SC.18.
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Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis
Christina M. Coughlin,Kevin E. Salhany,Michael S. Gee,Denise C. LaTemple,Serguei V. Kotenko,Xiaojing Ma,Giorgia Gri,Maria Wysocka,Ji Eun Kim,Li Liu,Fang Liao,Joshua M. Farber,Sidney Pestka,Giorgio Trinchieri,William M. F. Lee,William M. F. Lee +15 more
TL;DR: IL-12 and IFNgamma inhibit tumor growth by inducing tumor cells to generate antiangiogenic activity.
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Max: functional domains and interaction with c-Myc.
TL;DR: Max can interact with c-Myc intracellularly in a manner dependent on the integrity of the helix-loop-helix and leucine zipper motifs, and may serve as a cofactor for c- myc in transcriptional activation or, by itself, as a transcriptional repressor.