Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.
S Muraoka,R G Miller +1 more
TLDR
Both normal mouse bone marrow and cells from T cell-containing colonies grown in vitro from normal bone marrow contain cells which can specifically suppress the development of cytotoxic T lymphocytes capable of recognizing alloantigens on the bone marrow or colony cells.Abstract:
Both normal mouse bone marrow and cells from T cell-containing colonies grown in vitro from normal bone marrow contain cells which can specifically suppress the development of cytotoxic T lymphocytes capable of recognizing alloantigens on the bone marrow or colony cells. Suppression, as assessed by reduction in cytotoxic activity, is produced by adding bone marrow or colony cells to mixed lymphocyte reactions between lymph node responder cells and irradiated histoincompatible spleen stimulator cells. The cytotoxic activity is reduced if the added bone marrow or colony cells are syngeneic or semisyngeneic to the stimulator cells but not if they are allogeneic. Suppression results from a reduction in the number of cytotoxic lymphocyte precursor cells activated in the cultures. The suppressor cells in bone marrow are radiation sensitive and Thy-1 negative; those in colonies grown from bone marrow are radiation resistant and Thy-1 positive.read more
Citations
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Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
Yisong Y. Wan,Richard A. Flavell +1 more
TL;DR: The generation of a mouse model, in which a bicistronic reporter expressing a red fluorescent protein has been knocked into the endogenous Foxp3 locus, is reported, which should greatly enhance the study of regulation and function of Foxp 3-expressing regulatory T cells.
Journal ArticleDOI
HLA-DR antigens: structure, separation of subpopulations, gene cloning and function.
TL;DR: The hutnan major histocompatibility complex, called the HLA region, is located on the short arm of chromosome 6 and is known to code for about six proteins expressed on the cell surface and several serum complement factors.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.
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Programmed cell death of T cells signaled by the T cell receptor and the alpha 3 domain of class I MHC.
TL;DR: As well as being activated or rendered unresponsive, mature T lymphocytes can be deleted, depending on the signals received by the cell, in both removal of autoreactive T cells and immunoregulation.
Journal ArticleDOI
An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it.
TL;DR: A type of suppression more closely related to the first postulate of self-reactive cells being suppressed by regulatory networks similar to those limiting the immune response against non-self determinants is described.
References
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TL;DR: The clonal selection theory of acquired immunity is studied as a theory of selection for immunity in the context of infectious disease.
Journal ArticleDOI
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?
R M Zinkernagel,R M Zinkernagel,R M Zinkernagel,G. N. Callahan,G. N. Callahan,G. N. Callahan,A Althage,A Althage,A Althage,S Cooper,S Cooper,S Cooper,Paul A. Klein,Paul A. Klein,Paul A. Klein,Jan Klein +15 more
TL;DR: Adult thymectomized, irradiated and bone marrow reconstituted mice, transplanted with an irradiated thymus of A origin, generate virus-specific cytotoxic T cells specific for infected A targets but not for B targets; this result formally demonstrates the crucial role of thymic epithelial cells in the differentiation of anti-self-H-2 specificities of T cells.
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Differential function of major histocompatibility complex antigens in T-lymphocyte activation.
TL;DR: The antigenic systems of the major histocompatibility complex can be subdivided into thoseWhich are serologically detectable and those which are detected in tests with mixed lymphocytes.
Journal ArticleDOI
H-2 antigens of the thymus determine lymphocyte specificity.
Pamela J. Fink,Michael J. Bevan +1 more
TL;DR: It is concluded from these and other experiments that H-2 antigens present on resident cells of the thymus determine the spectrum of specificity of T cells which mature in thatThymus and eventually make up the peripheral T- cell pool.