L
Leo Lefrançois
Researcher at University of Connecticut Health Center
Publications - 175
Citations - 21851
Leo Lefrançois is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 77, co-authored 175 publications receiving 20850 citations. Previous affiliations of Leo Lefrançois include Upjohn & University of Connecticut.
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Journal ArticleDOI
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
TL;DR: In response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells, pointing to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.
TL;DR: The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors, and shows that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells.
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Cytokine control of memory T-cell development and survival
TL;DR: This work follows the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell.
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Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes
Thomas Goodman,Leo Lefrançois +1 more
TL;DR: It is reported that most mature T cells residing in the murine intestinal epithelium express CD3-associated TCRs composed of γ-chains distilphide-linked to a protein resembling the δ-chain.
Journal ArticleDOI
Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection
John R. Teijaro,Damian Turner,Quynh Mai Pham,E. John Wherry,Leo Lefrançois,Donna L. Farber,Donna L. Farber +6 more
TL;DR: A new class of lung tissue-resident memory CD4 T cells that exhibit tissue tropism and retention independent of Ag or inflammation is identified, important for targeting local protective responses in vaccines and immunotherapies.