Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome.
Mira Meeus,Jo Nijs +1 more
TLDR
The hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS is proposed, based on the hyperalgesia and allodynia reported in C FS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, in addition to the typical personality styles seen in Cfs and on the brain abnormalities shown on brain images.Abstract:
In addition to the debilitating fatigue, the majority of patients with chronic fatigue syndrome (CFS) experience chronic widespread pain. These pain complaints show the greatest overlap between CFS and fibromyalgia (FM). Although the literature provides evidence for central sensitization as cause for the musculoskeletal pain in FM, in CFS this evidence is currently lacking, despite the observed similarities in both diseases. The knowledge concerning the physiological mechanism of central sensitization, the pathophysiology and the pain processing in FM, and the knowledge on the pathophysiology of CFS lead to the hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS. This hypothesis is based on the hyperalgesia and allodynia reported in CFS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, on the typical personality styles seen in CFS and on the brain abnormalities shown on brain images. To examine the present hypothesis more research is required. Further investigations could use similar protocols to those already used in studies on pain in FM like, for example, studies on temporal summation, spatial summation, the role of psychosocial aspects in chronic pain, etc.read more
Citations
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The association of sleep and pain: an update and a path forward
TL;DR: A critical review of the recent prospective and experimental research on the association of sleep and pain tries to identify trends suggestive of directionality and potential mechanisms to guide future clinical efforts to develop and augment treatments for chronic sleep disturbance and chronic pain.
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The Effect of Neuroscience Education on Pain, Disability, Anxiety, and Stress in Chronic Musculoskeletal Pain
TL;DR: There is compelling evidence that an educational strategy addressing neurophysiology and neurobiology of pain can have a positive effect on pain, disability, catastrophization, and physical performance in chronic MSK pain.
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The long-term costs of traumatic stress: intertwined physical and psychological consequences
TL;DR: An increasing body of literature suggests that the effects of traumatic stress need to be considered as a major environmental challenge that places individual's physical and psychological health equally at risk.
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Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice
TL;DR: In this article, a mechanism-based clinical guidelines for the recognition of central sensitization in patients with musculoskeletal pain are provided, where the authors apply the science of nociceptive and pain processing neurophysiology to the practice of manual therapy.
Journal ArticleDOI
How to explain central sensitization to patients with ‘unexplained’ chronic musculoskeletal pain: Practice guidelines
Jo Nijs,C. Paul van Wilgen,Jessica Van Oosterwijck,Miriam van Ittersum,Miriam van Ittersum,Mira Meeus +5 more
TL;DR: Face-to-face sessions of pain physiology education, in conjunction with written educational material, are effective for changing pain cognitions and improving health status in patients with various chronic musculoskeletal pain disorders.
References
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Journal ArticleDOI
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.
Frederick Wolfe,Hugh A. Smythe,Muhammad B. Yunus,Robert M. Bennett,Claire Bombardier,Don L. Goldenberg,Peter Tugwell,Stephen M. Campbell,Micha Abeles,Patricia Clark,Adel G. Fam,Stephen J. Farber,Justus J. Fiechtner,C. Michael Franklin,Robert A. Gatter,Daniel Hamaty,James A. Lessard,Alan S. Lichtbroun,Alfonse T. Masi,Glenn A. McCain,W. John Reynolds,Thomas J. Romano,I. Jon Russell,Robert P. Sheon +23 more
TL;DR: Criteria for the classification of fibromyalgia are widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites, and no exclusions are made for the presence of concomitant radiographic or laboratory abnormalities.
Journal ArticleDOI
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Keiji Fukuda,Sharon E. Straus,Ian B. Hickie,Michael Sharpe,James G. Dobbins,Anthony L. Komaroff +5 more
TL;DR: A conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome are developed that cover the clinical and laboratory evaluation of persons with unexplained fatigue; the identification of underlying conditions that may explain the presence of chronic fatigue; revised criteria for defining cases of the Chronic fatigue syndrome; and a strategy for dividing the chronic Fatigue syndrome and other unexplained cases of Chronic fatigue into subgroups.
Book
Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Journal ArticleDOI
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art
TL;DR: In this article, the authors reviewed the existing evidence for the mediating role of pain-related fear, and its immediate and long-term consequences in the initiation and maintenance of chronic pain disability.
Journal Article
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
TL;DR: A review of the existing evidence for the mediating role of pain‐related fear, and its immediate and long‐term consequences in the initiation and maintenance of chronic pain disability, and the implications of the recent findings for the prevention and treatment of chronic musculoskeletal pain.
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The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.
Frederick Wolfe,Hugh A. Smythe,Muhammad B. Yunus,Robert M. Bennett,Claire Bombardier,Don L. Goldenberg,Peter Tugwell,Stephen M. Campbell,Micha Abeles,Patricia Clark,Adel G. Fam,Stephen J. Farber,Justus J. Fiechtner,C. Michael Franklin,Robert A. Gatter,Daniel Hamaty,James A. Lessard,Alan S. Lichtbroun,Alfonse T. Masi,Glenn A. McCain,W. John Reynolds,Thomas J. Romano,I. Jon Russell,Robert P. Sheon +23 more