Showing papers in "The Journal of Pain in 2009"

TL;DR: The major triggers that initiate and maintain central sensitization in healthy individuals in response to nociceptor input and in patients with inflammatory and neuropathic pain are reviewed, emphasizing the fundamental contribution and multiple mechanisms of synaptic plasticity caused by changes in the density, nature, and properties of ionotropic and metabotropic glutamate receptors.

TL;DR: Current human findings regarding sex differences in experimental pain indicate greater pain sensitivity among females compared with males for most pain modalities, including more recently implemented clinically relevant pain models such as temporal summation of pain and intramuscular injection of algesic substances.

TL;DR: Safe and effective chronic opioid therapy for chronic noncancer pain requires clinical skills and knowledge in both the principles of opioid prescribing and on the assessment and management of risks associated with opioid abuse, addiction, and diversion.

TL;DR: This review reveals the persistence of racial and ethnic disparities in acute, chronic, cancer, and palliative pain care across the lifespan and treatment settings, with minorities receiving lesser quality pain care than non-Hispanic whites.

TL;DR: The background for the different methods, the use in basic pain experiments on healthy volunteers, how they can be applied in drug profiling, and the applications in clinical practice are described.

TL;DR: Critical research gaps on use of opioids for chronic noncancer pain include: lack of effectiveness studies on long-term benefits and harms of opioids; insufficient evidence to draw strong conclusions about optimal approaches to risk stratification, monitoring, or initiation and titration of opioid therapy; and lack of evidence on the utility of informed consent and opioid management plans.

TL;DR: Data is presented from functional, structural, and molecular imaging studies in patients and animals supporting the notion that it might be time to reconsider chronic pain as a disease.

TL;DR: Evidence on prediction and identification of aberrant drug-related behaviors is limited, and no reliable evidence exists on accuracy of urine drug screening, pill counts, or prescription drug monitoring programs; or clinical outcomes associated with different assessment or monitoring strategies.

TL;DR: The high prevalence rates of pain and comorbid depression point to the clinical importance of assessing depression in chronic pain samples and suggest that certain demographic groups with chronic pain may especially benefit from depression screenings.

TL;DR: A meta-analysis showed that the thigh thrust test, the compression test, and 3 or more positive stressing tests have discriminative power for diagnosing SI joint pain.

TL;DR: Assessment of pain sensitivity may be relevant for the prevention, evaluation, and treatment of acute and chronic pain in patients with the same disease or trauma and large individual differences in pain sensitivity can complicate diagnosis and pain treatment and can confound clinical trials.

TL;DR: The history of FM and its diagnosis, evidence supporting central augmentation of pain in FM, potential mechanisms ofcentral augmentation, current approaches to integrated care of FM, and areas of active collaboration between FM research and other chronic pain conditions are reviewed.

TL;DR: In this article, a pooled individual data (PID)-based meta-analysis collectively assessed the analgesic effect of repetitive transcranial magnetic stimulation (rTMS) on various neuropathic pain states based on their neuroanatomical hierarchy.

TL;DR: Results showed that diminished DNIC was a significant partial mediator of the relation between greater pain-related catastrophizing and more severe pain ratings, and supported the hypothesis that the heightened pain reported by individuals higher in pain catastrophization may be related to a disruption in the endogenous modulation of pain.

TL;DR: Evidence is presented for several unique characteristics of geriatric pain: difficulty using Visual Analog Scales, increased vulnerability to neuropathic pain, decreased vulnerability to acute pain related to visceral pathology, prolonged recovery from tissue and nerve injury, and differences in the relationships among psychosocial factors important in adjustment to chronic pain.

TL;DR: After moderate exercise, CFS and CFS-FMS patients show enhanced gene expression for receptors detecting muscle metabolites and for SNS and IS, which correlate with these symptoms, which suggest possible new causes, points for intervention, and objective biomarkers for these disorders.

TL;DR: Investigating bilateral, widespread pressure hypersensitivity in women with myofascial temporomandibular disorders without concomitant comorbid conditions revealed the presence of bilateral and widespread pressure-pain hypersensitivity, suggesting that widespread central sensitization is involved in my ofascial TMD women.

TL;DR: Self-medication of pain with alcohol is most common among younger nonHispanic white males and associated with pain frequency, depression, and use of pain medications, and in younger adults.

TL;DR: The results indicate that patients with chronic pain managed with opioids and methadone-maintained subjects are hyperalgesic when assessed by the cold pressor test but not by the electrical stimulation test, and adds to the growing body of evidence that chronic opioid exposure increases sensitivity to some types of pain.

TL;DR: It is concluded that cupping therapy may be effective in relieving the pain and other symptoms related to CTS and related mechanisms remains to be clarified.

TL;DR: These findings support the hypothesis that both FMS and TMD may frequently involve dysregulation of beta-adrenergic activity that contributes to altered cardiovascular and catecholamine responses and to severity of clinical pain.

TL;DR: The preoperative anxiolysis with melatonin or clonidine reduced postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy and the effects these 2 drugs were equivalent and greater than with placebo.

TL;DR: The role of pain temporal summation assessed preoperatively as a significant psychophysical predictor for acute postoperative pain intensity is proposed and individual susceptibility toward a greater summation response may characterize patients who are potentially vulnerable to augmented POP.

TL;DR: An extended NMQ (NMQ-E) is developed to collect greater information regarding musculoskeletal pain, examine test-retest reliability and the reproducibility of alternate administration methods, and can be administered via self-completion and personal interview.

TL;DR: Data presented here show individuals with chronic pain have more distress and disability when they manifest more fear of anxiety symptoms, and behavior patterns of "acceptance" and "mindfulness" may reduce this effect.

TL;DR: The biochemistry, second messenger pathways and hetero-receptor coupling that are activated by ET receptors, the cellular physiological responses to ET receptor activation, and the contribution to pain of such mechanisms occurring in the periphery and the CNS are reviewed.

TL;DR: Results indicate that values interventions make a significant contribution and improvement to acceptance interventions, which may be of interest to clinicians who provide psychological treatment to individuals with chronic pain.

TL;DR: The study suggests that the Internet can be an efficient mode for delivering self-care education to older adults with chronic pain and has potential benefits that complement clinical care and suggest that the intervention may have an immediate impact on reducing pain.

TL;DR: The findings of this study distinguish between the neuropathic pain syndromes produced by members of a single chemical class of anticancer drugs and suggest that the underlying mechanisms of various forms of peripheral neuropathy may be different.

TL;DR: Data is presented showing mechanical hyperalgesia persisting for up to 28 days after exposure to sound stress, with evidence that the sympathoadrenal axis mediator epinephrine plays a major role in the induction as well as maintenance of stress-induced enhancement of mechanical hyper algesia.