Journal ArticleDOI
Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys
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TLDR
The data indicate that the social and physical environment during development influences the morphology of cerebellar Purkinje cells.Abstract:
Dendritic branching in Purkinje and granule cells and the diameters of Purkinje cell somas were compared in several cerebellar areas of monkeys reared in isolation, with social experience, or in a large colony. In the colony-reared monkeys, spiny branchlets of Purkinje cells were more extensive in the paraflocculus and the nodulus than they were in the other two groups. Granule cell dendritic branching in the paraflocculus and nodulus did not differ across groups. In addition, Purkinje cell somas were larger in the uvula and the nodulus of the colony animals than in the other groups. These data indicate that the social and physical environment during development influences the morphology of cerebellar Purkinje cells.read more
Citations
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Experience and brain development.
TL;DR: A new categorization scheme based upon the type of information stored and the brain mechanisms that appear to be involved in storing it is proposed, which offers a new view more in accord with neural mechanisms than were terms like "critical" or "sensitive period."
Journal ArticleDOI
Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
James E. Black,Krystyna R. Isaacs,Brenda J. Anderson,Adriana A. Alcantara,William T. Greenough +4 more
TL;DR: The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive.
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The neurobiology of learning and memory
TL;DR: Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
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Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder.
TL;DR: A developmental model of risk, risk processes, symptom emergence, and adaptation in ASD is described that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder.
Book
Brain plasticity and behavior
TL;DR: It is now clear that experience produces multiple, dissociable changes in the brain including increases in dendritic length, increases (or decreases) in spine density, synapse formation, increased glial activity, and altered metabolic activity.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in rats
TL;DR: In one experiment rats were injected with single does of thymidine‐H3 at 6 hours, 2, 6 and 13 days of age, or with multiple doses during two periods of early life, and were killed when 2, 4 and 6 months old.
Journal ArticleDOI
Purkinje cell activity during motor learning.
TL;DR: Results are consistent with theoretical proposals that motor learning takes place in the cerebellum through changes in the strength of transmission of parallel fiber synapses on P-cells caused by the climbing fiber input and suggest that climbing fiber firing causes a decrease in thestrength of parallel Fiber synapses.
Journal ArticleDOI
Total social isolation in monkeys
TL;DR: Human social isolation is recognized as a problem of vast importance and its effects are deleterious to personal adjustment, normal heterosexual development, and control of aggressive and delinquent behaviors.
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