Journal ArticleDOI
Challenges and Opportunities for Pancreatic Cancer Immunotherapy
TLDR
Novel immunotherapy strategies currently under investigation to confer antigen specificity, enhance T cell effector function, and neutralize immunosuppressive elements within the tumor microenvironment that may be rationally combined to untangle the web of immune resistance in PDA and other tumors are reviewed.About:
This article is published in Cancer Cell.The article was published on 2020-12-14. It has received 201 citations till now. The article focuses on the topics: Immunotherapy & Tumor microenvironment.read more
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Trp53R172H and kmsg12d cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Sunil R. Hingorani,Lifu Wang,Asha S. Multani,Chelsea Combs,Therese B. Deramaudt,Ralph H. Hruban,Anil K. Rustgi,Sandy Chang,David A. Tuveson +8 more
TL;DR: In this article, the authors defined the genetic requirements for pancreatic ductal adenocarcinoma (PDA) and targeted concomitant endogenous expression of Trp53 R172H and Kras G12D to reveal the cooperative development of invasive and widely metastatic carcinoma that recapitulates the human disease.
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Christina Pfirschke,Camilla Engblom,Steffen Rickelt,Virna Cortez-Retamozo,Christopher Garris,Ferdinando Pucci,Takahiro Yamazaki,Vichnou Poirier-Colame,Andita Newton,Younes Redouane,Yi Jang Lin,Gregory R. Wojtkiewicz,Yoshiko Iwamoto,Mari Mino-Kenudson,Tiffany Huynh,Richard O. Hynes,Gordon J. Freeman,Guido Kroemer,Laurence Zitvogel,Ralph Weissleder,Mikael J. Pittet +20 more
TL;DR: It is shown that autochthonous tumors that lacked T-cell infiltration and resisted current treatment options could be successfully sensitized to host antitumor T cell immunity when appropriately selected immunogenic drugs were used.
Journal ArticleDOI
Cell death in pancreatic cancer: from pathogenesis to therapy.
TL;DR: In this paper, the molecular machinery of cell death, discuss the complexity and multifaceted nature of lethal signalling in pancreatic ductal adenocarcinoma (PDAC) cells, and highlight the challenges and opportunities for activating cell death pathways through precision oncology treatments.
Journal ArticleDOI
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
TL;DR: In this article , a review summarizes the multilevel relationship between antitumor immunity and non-apoptotic regulated cell death (RCD), including autophagy, ferroptosis and necroptosis.
Journal ArticleDOI
Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming
Sen Yang,Qiaofei Liu,Quan Liao +2 more
TL;DR: In this article, the authors comprehensively reviewed the latest researches on the origin, polarization, functions, and reprogramming of TAMs in pancreatic ductal adenocarcinoma (PDAC).
References
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Journal ArticleDOI
Immune cytolytic activity stratifies molecular subsets of human pancreatic cancer
TL;DR: Examination of the immune landscape of PDA as it relates to aspects of tumor biology suggests that intrinsic oncogenic processes drive immune inactivity in human PDA, highlighting the potential importance of immune checkpoints other than PD-L1/PD-1 as therapeutic targets in this lethal disease.
Journal ArticleDOI
IFNγ and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma
Kristen B. Long,Whitney L. Gladney,Graham M. Tooker,Kathleen Graham,Joseph A. Fraietta,Gregory L. Beatty +5 more
TL;DR: It is reported that CD40 agonists improve chemotherapy efficacy in pancreatic carcinoma by redirecting tumor-infiltrating monocytes/macrophages to induce fibrosis degradation that is dependent on MMPs.
Journal ArticleDOI
CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma.
TL;DR: Prominent expression of a neutrophil gene signature in a subset of human pancreatic adenocarcinoma (PDA) is reported, highlighting the potential utility of targeting this axis as a novel therapy for this deadly disease.
Journal ArticleDOI
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.
Juliana Candido,Jennifer P. Morton,Peter Bailey,Andrew D. Campbell,Saadia A. Karim,Thomas Jamieson,Laura Lapienyte,Aarthi Gopinathan,William Clark,Ewan J. McGhee,Jun Wang,Monica Escorcio-Correia,Raphaël Zollinger,Rozita Roshani,Lisa Drew,Loveena Rishi,Rebecca Arkell,T.R. Jeffry Evans,Colin Nixon,Duncan I. Jodrell,Robert W. Wilkinson,Andrew V. Biankin,Simon T. Barry,Frances R. Balkwill,Owen J. Sansom +24 more
TL;DR: It is revealed that macrophages are the dominant leukocyte population both in human PDAC stroma and autochthonous models, with an important functional contribution to the squamous subtype of humanPDAC.
Journal ArticleDOI
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors
Qiong J. Wang,Zhiya Yu,Kayla Griffith,Ken-ichi Hanada,Nicholas P. Restifo,James Chih-Hsin Yang +5 more
TL;DR: The success of adoptive transfer of TCR-engineered T cells against melanoma and other cancers supports clinical trials with these T cells that recognize mutated KRAS in patients with a variety of common cancer types.
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