Changes in muscle T2 and tissue damage after downhill running in mdx mice.
Sunita Mathur,Ravneet Vohra,Sean Germain,Sean C. Forbes,Nathan Bryant,Krista Vandenborne,Glenn A. Walter +6 more
TLDR
The effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice is compared.Abstract:
Introduction—This study compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice. Methods—Mice underwent either downhill (n=11 mdx, n=6 controls) or horizontal running (n=9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterwards (~20 min), 24, and 48 hours following exercise. Results—A higher percentage of pixels with elevated T2 in the lower hindlimb muscles was observed in the mdx mice compared to controls both pre-exercise (p < 0.001) and at each time point following downhill running (p < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T2. Discussion—Downhill running provides a stimulus for inducing acute changes in muscle T2 in mdx mice. MRI is a non-invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously.read more
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Skeletal Muscle Quantitative Nuclear Magnetic Resonance Imaging and Spectroscopy as an Outcome Measure for Clinical Trials.
Pierre G. Carlier,Benjamin Marty,Olivier Scheidegger,Paulo Loureiro de Sousa,P. Baudin,Eduard Snezhko,Dmitry Vlodavets +6 more
TL;DR: The versatility of contrast generated by NMR has opened many additional possibilities for characterization of the skeletal muscle and will result in the proposal of more NMR biomarkers, which will reinforce the attractiveness of NMR outcome measures and facilitate their integration in clinical research trials.
Journal ArticleDOI
T2 mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross‐sectional study of lower leg muscles in 5–15‐year‐old boys with Duchenne muscular dystrophy
Ishu Arpan,Sean C. Forbes,Donovan J. Lott,Claudia R. Senesac,Michael J. Daniels,William T. Triplett,Jasjit Deol,H. Lee Sweeney,Glenn A. Walter,Krista Vandenborne +9 more
TL;DR: The elevated T2 measures with and without fat saturation at all ages of DMD examined, compared with unaffected controls indicate that the dystrophic muscles have increased regions of damage, edema and fat infiltration.
Journal ArticleDOI
Redox biology of exercise: an integrative and comparative consideration of some overlooked issues.
Michalis G. Nikolaidis,Antonios Kyparos,Chrysoula Spanou,Vassilis Paschalis,Anastasios A. Theodorou,Ioannis S. Vrabas +5 more
TL;DR: ‘exercise-induced oxidative stress’ is not an ‘oddity’ associated with a particular type of exercise, tissue or species, Rather, oxidative stress constitutes a ubiquitous fundamental biological response to the alteration of redox homeostasis imposed by exercise.
Journal ArticleDOI
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS
Ishu Arpan,Rebecca J. Willcocks,Sean C. Forbes,Richard S. Finkel,Donovan J. Lott,William D. Rooney,William T. Triplett,Claudia R. Senesac,Michael J. Daniels,Barry J. Byrne,Erika Finanger,Barry S. Russman,Barry S. Russman,Dah Jyuu Wang,Gihan Tennekoon,Glenn A. Walter,H.L. Sweeney,Krista Vandenborne +17 more
TL;DR: The ability of MRI/MRS to detect therapeutic effects of corticosteroids in reducing inflammatory processes in skeletal muscles of boys with DMD is demonstrated, suggesting reduced inflammation/damage and fat infiltration with treatment.
Journal ArticleDOI
Mr measurements of muscle damage and adaptation after eccentric exercise
TL;DR: The long-term pattern of T2 relaxation times and muscle volume changes in human skeletal muscle after intense eccentric exercise is clarified and whether the T2 response exhibits an adaptation to repeated bouts is determined.
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