Andrea Kelly

TL;DR: It is demonstrated that dystrophin-deficient muscle fibers of the mdx mouse exhibit an increased susceptibility to contraction-induced sarcolemmal rupture, which strongly support the proposition that the primary function of dyStrophin is to provide mechanical reinforcement to the sarcolemma and thereby protect it from the membrane stresses developed during muscle contraction.

TL;DR: It is proposed that dystrophin deficiency alters the threshold for work-induced injury and provides a quantitative framework for studying the pathogenesis of dystrophy and extend the application of the mdx mouse as an animal model.

TL;DR: Most methods to adjust BMC/BMD Z-scores for height were biased by age and/or HAZ, and Adjustments using HAZ were least biased relative to HAZ and age and can be used to evaluate the effect of short or tall stature on BMC/ BMD Z -scores.

TL;DR: Through S1 nuclease mapping using a specific cDNA probe, it is demonstrated that the slow myosin heavy-chain (MHC) gene is expressed in bulk hind limb muscle obtained from the 18-d rat fetus and hypothesize that, in this muscle, the nerve protects and amplifies initial programs of slow MHC synthesis.

TL;DR: A meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores, identifies three novel loci that likely represent age-related differences in strength of the associations with bodymass index.