Journal ArticleDOI
Chemical inactivation of human immunodeficiency virus in vitro.
TLDR
The results suggest that HIV inactivation is dependent on the viral concentration, the time of incubation in presence of the putative disinfectant and the degree of virucidal activity of the latter.About:
This article is published in Journal of Virological Methods.The article was published on 1992-04-01. It has received 30 citations till now.read more
Citations
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Journal ArticleDOI
Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness
TL;DR: Hypochlorous acid proved to exert a rapid inhibitory effect on DNA synthesis, consistent with its primary role in bacterial killing by phagocytes, and Cytotoxicity produced by increasing NaOCl concentrations and assessed by measuring both mitochondrial function and cell DNA synthesis was reduced.
Journal ArticleDOI
The physiology and pharmacology of singlet oxygen.
TL;DR: Chloramines are selective and stable chemical generators of hypochlorite and chloramines and are both a signal and a weapon with therapeutic potency against very different pathogens, such as microbes, virus, cancer cells and thrombi.
Journal ArticleDOI
Inactivation of human immunodeficiency virus type 1 by alcohols
TL;DR: Protocols to measure the efficacy of alcohols against HIV in suspension and dried onto surfaces in the presence of high and low protein concentrations showed that high titres of HIV in suspended form were rapidly inactivated by 70% ethanol, independent of the protein load.
Journal ArticleDOI
In vitro and in vivo evaluation of lyophilized bovine bone biocompatibility
Carlos Roberto Galia,Carlos Alberto de Souza Macedo,Ricardo Rosito,Tielle Müller de Mello,Lourdes Maria Araújo Quaresma Camargo,Luis Fernando Moreira +5 more
TL;DR: The protocol changes established by the authors to prepare lyophilized bovine cancellous bone at a semi-industrial scale is reproducible and yielded a product with excellent biocompatibility.
Journal ArticleDOI
Susceptibility of HIV to inactivation by disinfectants and ultraviolet light.
TL;DR: A range of commercially available disinfectants with active constituents including glutaraldehyde, chlorine, phenolics, alcohol, iodine and quaternary ammonium compounds was tested, finding cell-associated HIV was more resilient than cell-free HIV and the effectiveness of the disinfectants was further compromised in the presence of blood.
References
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Journal ArticleDOI
Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS
TL;DR: A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS), and it provides large amounts of virus for detailed molecular and immunological analyses.
Journal ArticleDOI
Plasma Viremia in Human Immunodeficiency Virus Infection
Robert W. Coombs,Ann C. Collier,Jean-P. Allain,Beverly Nikora,Michael Leuther,George F. Gjerset,Lawrence Corey +6 more
TL;DR: It is concluded that plasma viremia is a more sensitive virologic marker of the clinical stage of HIV infection and viral replication than the presence of p24 antigen or antibody in plasma.
Journal ArticleDOI
Stability and inactivation of HTLV-III/LAV under clinical and laboratory environments.
TL;DR: The stability of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) under environmental conditions encountered in a clinical or laboratory setting and its inactivation by commonly used chemical disinfectants were investigated.
Journal ArticleDOI
Inactivation of htlv-iii/lav-infected cultures of normal human lymphocytes by nonoxynol-9 in vitro
D Hicks,LindaS. Martin,JaneP. Getchell,JanetL. Heath,D. P. Francis,J.Steve Mcdougal,James W. Curran,Bruce Voeller +7 more
TL;DR: In vitro inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by nonoxynol-9 a nonionic surfactant seems to inactivate HTLV- III in vitro while 1% or more reduces live counts of the target lymphocytes.
Journal ArticleDOI
Inactivation of lymphadenopathy associated virus by chemical disinfectants
TL;DR: Reverse transcriptase activity of lymphadenopathy associated virus was assayed after exposure to various standard chemical disinfectants, and 25% ethanol or 1% glutaraldehyde should prove sufficient to disinfect medical instruments and 0.2% sodium hypochlorite for cleaning floors and benches.