Chemical Properties of Quinol Phosphate Esters and Inhibition of Alcohol Dehydrogenase by Them

TLDR: Eto et al. as mentioned in this paper found that quinol phosphates are susceptible to oxidation and inhibit the SH-enzyme alcohol dehydrogenase, which has been known as a malathion synergist.

Abstract: In a previous paper (Eto et al., 1975), we found the metabolic formation of a quinol phosphate in houseflies from triphenyl phosphate, which has been known as a malathion synergist (Plapp et al., 1963). It has been also reported that the fungicide edifenphos (S, S-diphenyl ethyl phosphorodithiolate ; HinosanQ) was partially metabolized through p-hydroxylation in Pyricularia oryzae (Uesugi and Tomizawa, 1971). Quinol phosphates are known to be activated oxidatively (Blackburn and Cohen, 1968). By oxidation, a quinol phosphate will give a quinone which may react with SH-compounds. This paper describes that quinol phosphates are susceptible to oxidation and inhibit the SH-enzyme alcohol dehydrogenase.