Journal ArticleDOI
Chiral stationary phase covalently bound with a chiral pseudo‐18‐crown‐6 ether for enantiomer separation of amino compounds using a normal mobile phase
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TLDR
The chiral recognition in host-guest interactions might contribute to this enantiomer separation of amino compounds in view of the correlation between the enantiomers selectivity observed in chromatography and the complexion in solution.About:
This article is published in Chirality.The article was published on 2005-01-01. It has received 45 citations till now. The article focuses on the topics: Chiral column chromatography & Chiral derivatizing agent.read more
Citations
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Journal ArticleDOI
Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review
TL;DR: This review surveys indirect and direct HPLC separations of biologically and pharmaceutically important enantiomers of amino acids and related compounds, with emphasis on the literature published from 2005.
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Development and Application of Crown Ether-based HPLC Chiral Stationary Phases
TL;DR: A review on the development of crown ether-based HPLC CSPs, their structural characteristics and applications to the resolution of racemic compounds including chiral drugs containing a primary or secondary amino group is presented in this article.
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Chiral Separation of Pharmaceuticals by High Performance Liquid Chromatography
TL;DR: In this paper, the usage of new materials as chiral stationary phases (CSPs) in liquid chromatography for enantiomeric discrimination is investigated in detail, and hyphenated techniques are very useful for chiral separation of HPLC, especially for separation of new pharmaceuticals.
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Preparation and application of HPLC chiral stationary phases based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid
TL;DR: The CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid have been very successful for the resolution of various primary amino compounds with the use of an aqueous mobile phase containing organic and acidic modifiers.
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Desorption electrospray ionization reactions between host crown ethers and the influenza neuraminidase inhibitor oseltamivir for the rapid screening of Tamiflu.
Leonard Nyadong,Edward G. Hohenstein,Kristin Johnson,C. David Sherrill,Michael D. Green,Facundo M. Fernández +5 more
TL;DR: Competitive host-guest chemistry on a desorption electrospray ionization mass spectrometry (DESI MS) platform is presented here as the basis for a rapid and quantitative screening method for assessing the quality of Tamiflu capsules with minimal sample preparation.
References
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Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid Chromatography
TL;DR: In this article, three representative macrocyctic compounds were covalently linked to silica gel and evaluated by HPLC for their ability to resolve racemic mixtures as well as for their stability and loadability.
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A Practical Guide for the Determination of Binding Constants
TL;DR: In this article, the binding constants of host-guest chemistry have to be determined on many occasions, and the basic principle and the practical issue of determining binding constants is discussed, together with a practical experimental guideline, a representative method for the determination of stoichiometry and for the evaluation of a complex concentration, precautions to be taken on setting upconcentration conditions of the titration experiment, and a data-treatment method and estimation of statistical errors.
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A covalently bonded teicoplanin chiral stationary phase for HPLC enantioseparations
TL;DR: It appears that teicoplanin is a widely applicable, highly effective chiral selector for HPLC enantioseparations.
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Host-guest complexation. 14. Host covalently bound to polystyrene resin for chromatographic resolution of enantiomers of amino acid and ester salts
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Chromatographic separation of racemic amino acids by use of chiral crown ether-coated reversed-phase packings.
TL;DR: Almost all the amino acids commonly found in proteins were finely separated into their enantiomers when a dilute aqueous solution of perchloric acid was used as the eluent.