Journal ArticleDOI
Chromosome changes (trisomy 15) in murine T-cell leukemia induced by 7,12-dimethylbenz(a)anthracene (DMBA)
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TLDR
The banding pattern of DMBA‐induced leukemias in C57BL/6 mice revealed a very constant chromosome pattern: the presence of trisomy 15 in almost all leukemic cells, which strongly suggests that chromosome 15trisomy is the first detectable specific chromosome change associated with the development of DM BA‐induced T‐cell lymphomas.Abstract:
The banding pattern of DMBA-induced leukemias in C57BL/6 mice revealed a very constant chromosome pattern: the presence of trisomy 15 in almost all leukemic cells. This finding strongly suggests that chromosome 15 trisomy is the first detectable specific chromosome change associated with the development of DMBA-induced T-cell lymphomas. A similar association was previously shown with regard to development of radiation-leukemia-virus-induced T-cell lymphoma. It is conceivable that in tumors of diverse etiologies common cytogenetic changes may appear in the same common target-cell precursor, by a process of the "convergent microevolution" type.read more
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References
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Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
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Localization of heterochromatin in human chromosomes
Frances E. Arrighi,T. C. Hsu +1 more
TL;DR: Heterochromatic regions in chromosomes of man, mainly at the centromeric areas, can be demonstrated with consistency using a special staining procedure.
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Banding in human chromosomes treated with trypsin.
Hong Wang,S. Fedoroff +1 more
TL;DR: Through modifications of the original methods used in the DNA hybridization work, techniques have been developed which make each chromosome identifiable and these observations were later made on human chromosomes.
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The Epstein-Barr Virus and Neoplasia
TL;DR: EBV can convert normal lymphocytes, which have a limited life span in vitro, into permanently growing cell lines that carry multiple copies of the viral genome per cell and express EBV-specific nuclear genes.
Journal ArticleDOI
Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.
TL;DR: Karyotypes of spontaneous thymomas of AKR mice were determined by trypsin-Giemsa banding methods and trisomy of chromosome 15 occurred in 10 of 11 leukemic mice.