F
Francis Wiener
Researcher at Karolinska Institutet
Publications - 82
Citations - 3091
Francis Wiener is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Chromosomal translocation & Chromosome 15. The author has an hindex of 30, co-authored 82 publications receiving 3080 citations. Previous affiliations of Francis Wiener include University of Manitoba.
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The Analysis of Malignancy by Cell Fusion: I. Hybrids Between Tumour Cells and L Cell Derivatives
TL;DR: In this paper, a wide range of different kinds of malignant cell were fused with certain derivatives of the L cell line and the ability of the resulting hybrid cells to grow progressively in vivo was examined.
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Genomic instability and apoptosis are frequent in p53 deficient young mice
TL;DR: It is found that cells from various organs of 4 to 6-week old p53-nullizygous (p53−/−) mice display aneuploidy and frequent gene amplification as well as evidence for apoptosis, indicating that a high number of aberrant cells is eliminated by p 53-independent pathways in vivo.
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Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas.
TL;DR: The karyotypes of pristane-induced mouse plasmacytomas support the theory that the nonrandom chromosomal changes in lymphoproliferative malignancies are associated with the type of the target cell, rather than with the etiological agent.
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Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations.
Michael Potter,Francis Wiener +1 more
TL;DR: Three model systems of plasmacytomagenesis that are associated with mutations that affect c-myc transcription were discussed and fundamental unanswered questions are whether these inflammatory tissues provide products such as oxidants in vivo that damage DNA and promote mutagenesis.
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Growth and antigenic properties of a biopsy-derived Burkitt's lymphoma in thymus-less (nude) mice.
TL;DR: In this article, a Burkitt's lymphoma was transferred to the congenitally athymic mouse mutant nude with biopsy material from a 7-year-old Kenyan girl.